| Gene Symbol | SAPPBETA |
| Amyloidogenic pathway | APP → sAPPβ + C99 → Amyloid-beta |
| Non-amyloidogenic pathway | APP → sAPPα + C83 |
| APP695 | Predominant neuronal isoform (695 amino acids) |
| APP751 | Contains a KPI domain (751 amino acids) |
| APP770 | Full-length isoform with KPI domain (770 amino acids) |
| Neuroprotective effects | N-terminal fragments can activate insulin receptor signaling |
| Synaptic plasticity | Modulates NMDA receptor function |
| Cellular stress response | Activates MAPK pathways |
| Neurogenesis | Promotes neural progenitor cell proliferation |
| Down syndrome | Trisomy 21 leads to increased APP gene dosage |
| Creutzfeldt-Jakob disease | Rapid neuronal loss releases APP fragments |
| Traumatic brain injury | Acute APP processing activation |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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