| Gene Symbol | ent-dise-bfd8f32d |
| Midbrain atrophy | The "Hummingbird sign" or "Penguin sign" on sagittal T1-weighted images, reflecting atrophy of the midbrain tegmentum[@savoiardo2020] |
| Superior cerebellar peduncle atrophy | Visible on axial images, reflecting degeneration of efferent cerebellar pathways[@tsuboi2003] |
| Third ventricle enlargement | Due to thalamic and hypothalamic atrophy[@kato2004] |
| Frontal lobe atrophy | Particularly in the precentral and superior frontal gyri |
| Red nucleus hyperintensity | On T2-weighted images in the red nucleus |
| Midbrain to pons ratio | Reduced in PSP vs. other parkinsonian disorders[@quattrone2008] |
| Superior cerebellar peduncle width | Correlates with clinical severity |
| Fronto-occipital fasciculus integrity | Assessed via diffusion tensor imaging |
| ^18F-AV-1451 (Flortaucipir) | Binds to paired helical filament tau, showing elevated binding inPSP subcortical regions[@mcfarland2025] |
| ^18F-APN-1607 | Second-generation tau PET ligand with improved sensitivity |
| KG Connections | 3 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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