Contents

Neuron-Specific Enolase (NSE) - Biomarker

🔬 Protein Info

Gene Symbol	NEURON
Chromosome	12p13
Protein Type	Enzyme
Function	is a glycolytic enzyme that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate in the glycolysis pathway.
Primary Expression	neuroendocrine cells) \|
Molecular Weight	~45 kDa (each subunit, 433 amino acids)
Amino Acids	433 aa
Pathways	NEURODEGENERATION, NEUROINFLAMMATION
GeneCards	NEURON
Human Protein Atlas	NEURON
Gene	ENO2
Isoforms	α (non-neuronal), β (muscle), γ (neuronal)
CSF elevations	Elevated in PD patients vs. healthy controls (Santos et al., 2020)
Neuronal loss	Reflects ongoing neuronal degeneration
Disease progression	Higher levels in moderate to severe AD
Associated Diseases	Alzheimer's disease
Known Drugs/Compounds	rabies virus glycoprotein peptide, RVG peptide
KG Connections	33 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING