| Gene Symbol | NEUROFASCIN |
| NFASC155 | Major isoform at the paranode, forms critical complexes with contactin-1 and caspr to maintain the paranodal junction |
| NFASC186 | Predominant at the axonal initial segment (AIS), partners with ankyrin-G to establish the AIS scaffold |
| ALS disease progression | Higher NFASC levels associated with faster disease progression; studies show correlation with neurofilament light chain (NfL) levels |
| Multiple sclerosis | CSF NFASC155 reflects demyelination and axonal loss; useful for monitoring disease activity |
| Parkinson's disease | Altered expression patterns in early-stage PD; potential early biomarker |
| Alzheimer's disease | Correlates with white matter integrity loss on MRI |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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