biomarker 2,020 words KG: protein
Contents

GAP-43 (Growth-Associated Protein 43) - Neuronal Regeneration Biomarker

🔬 Protein Info
Gene Symbolprotein
Chromosome3q13.31
FunctionEarly Disease Stages:
N-terminal domain (1-40 aa)Contains palmitoylation sites (Cys-3, Cys-4) for membrane anchoring
Calmodulin-binding domain (100-150 aa)Regulates calcium-dependent signaling
Axonal targeting domain (150-238 aa)Directs protein to growth cones and synaptic terminals
KG Connections6 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (22)

Trans-Synaptic Adhesion Molecule Modulation
Score: 0.54
Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.51
← Prevpg 2/2

Related Analyses (11)

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neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (5)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40
Axonal Transport Dysfunction Validation in Parkinson's Disea
clinical · proposed · Score: 0.40
Gap Junction Dysfunction Validation in Parkinson's Disease
clinical · proposed · Score: 0.40
Selective Neuronal Vulnerability to Aging — Mapping Why Spec
validation · proposed · Score: 0.40

Knowledge Graph (6 edges)

NEMO interacts_with protein
protein involved_in amino acid sequence
protein involved_in secondary structure
protein involved_in protein folding
protein mediates protein_quantitative_trait_loci
biomarkers-gap-43-growth-associated-protein describes protein

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