| Gene Symbol | BIOMARKER |
| Function | Binds long-chain fatty acids, retinoic acid, and other lipids |
| Primary Expression | Heart, skeletal muscle, brain (neurons), kidney |
| Structure | Beta-barrel structure with hydrophobic core |
| Primary expression | Neurons (pyramidal cells, Purkinje cells) |
| Regional distribution | High in cortex, hippocampus, cerebellum |
| Function in brain | Lipid transport, synaptic plasticity, neuroprotection |
| Necrosis | cell membrane rupture |
| Apoptosis | controlled release from dying cells |
| Exocytosis | active release under certain conditions |
| Membrane permeability | increased permeability during injury |
| Correlates with cognitive decline | higher levels = worse performance |
| Predicts progression | high baseline predicts MCI→AD conversion |
| Combined with other biomarkers | enhances diagnostic accuracy |
| Elevated in early PD | potential early marker |
| Correlates with motor severity | UPDRS scores |
| KG Connections | 1 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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