| Gene Symbol | CONTACTIN1 |
| Neurofascin-155 (NFASC155) | Forms the paranodal junction complex, essential for node of Ranvier structure |
| Caspr (CNTNAP1) | Partner protein at the paranode, forming the Caspr-contactin complex |
| Notch1 | Involved in developmental signaling and myelination regulation |
| L1CAM | Cooperative interactions in neural development and axon guidance |
| Fyn kinase | Involved in Contactin-1 signaling and myelination |
| Serum elevations | Elevated serum Contactin-1 correlates with demyelination burden as assessed by nerve conduction studies (Kouton et al., 2020) |
| Treatment monitoring | Levels decrease following successful immunotherapy (IVIg, steroids) |
| Prognosis | Elevated levels predict slower recovery and residual deficits |
| Autoantibodies | Anti-Contactin-1 antibodies found in a subset of CIDP patients |
| CSF elevations | CSF Contactin-1 levels peak in the acute phase (weeks 1-3) (Martin et al., 2018) |
| Axonal involvement | Higher levels correlate with evidence of axonal damage on EMG |
| Variant-specific | Particularly elevated in the acute motor axonal neuropathy (AMAN) variant |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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