| Gene Symbol | ent-gene-8c4c3123 |
| Mechanism | mHTT loses ability to sequester REST in cytoplasm |
| REST nuclear translocation | REST enters cortical neuron nuclei |
| Gene repression | REST binds to RE1 elements in BDNF promoter regions |
| Result | Reduced activity-dependent BDNF transcription |
| Sp1 sequestration | mHTT disrupts Sp1-mediated BDNF transcription |
| CREB dysfunction | Altered cAMP response element binding protein activity |
| Epigenetic silencing | Histone deacetylation at BDNF promoters |
| Scaffold function | Wild-type huntingtin acts as scaffold for molecular motors |
| Dynein complex | Facilitates retrograde transport from terminals to cell bodies |
| Kinesin-dependent transport | Enables anterograde BDNF vesicle movement |
| Motor protein dysfunction | mHTT impairs dynein/dynactin complex function |
| Vesicle trafficking | BDNF-containing vesicles fail to traffic efficiently |
| Axonal transport defects | General disruption of microtubule-based transport |
| HAP40 interaction | mHTT-HAP40 complex disrupts organelle trafficking |
| Dynein light chain binding | Altered interaction with dynein components |
| KG Connections | 10 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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