| Typical Onset | MSA often has earlier autonomic involvement |
| Orthostatic hypotension | 30-50% of patients |
| Urinary dysfunction | Urinary urgency and frequency, but less severe than in MSA |
| Gastrointestinal dysfunction | Constipation is common; dysphagia can occur |
| Sexual dysfunction | 30-40% of male patients |
| Sweating abnormalities | Hyperhidrosis or hypohidrosis |
| Urinary symptoms | 40-60% of patients |
| Constipation | 50-70% of patients |
| Sweating changes | 20-30% of patients |
| Progression | MSA has more rapid progression |
| Severity | MSA has more severe autonomic failure |
| Impact | Can significantly affect quality of life |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
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