gene 2,920 words KG: ent-gene-b2d5f914
Contents

ASC (PYCARD)

🧬 Gene Info
Gene Symbolent-gene-b2d5f914
Chromosome16p11.2
PhosphorylationTBK1 phosphorylates ASC at Ser194, enhancing its ability to form specks and amplifying innate immune responses[@hara2013]
UbiquitinationK63-linked ubiquitination of ASC regulates its stability and inflammasome activity
SUMOylationSUMO modification at specific lysine residues modulates ASC function
KG Connections3 knowledge graph edges
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Related Hypotheses (20)

Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78
Retinal Vascular Microcirculation Rescue
Score: 0.72
HDAC3-Selective Inhibition for Clock Reset
Score: 0.71
Endothelial Glycocalyx Regeneration via Syndecan-1 Upregulat
Score: 0.71
SASP-Mediated Complement Cascade Amplification
Score: 0.70
Complement C1q Mimetic Decoy Therapy
Score: 0.69
...
Score: 0.68
Complement C1QA Spatial Gradient in Cortical Layers
Score: 0.68
Complement C1q Subtype Switching
Score: 0.66
Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuro
Score: 0.61
Aquaporin-4 Polarization Rescue
Score: 0.73
Microglial Purinergic Reprogramming
Score: 0.70
Microbial Inflammasome Priming Prevention
Score: 0.65
Glial Glycocalyx Remodeling Therapy
Score: 0.65
Ephrin-B2/EphB4 Axis Manipulation
Score: 0.64
Vagal Afferent Microbial Signal Modulation
Score: 0.62
Sphingolipid Metabolism Reprogramming
Score: 0.62
Gut Barrier Permeability-α-Synuclein Axis Modulation
Score: 0.53
Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.51
Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.48

Related Analyses (11)

Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Immune atlas neuroinflammation analysis in neurodegeneration
Neuroinflammation · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived

Knowledge Graph (3 edges)

24469054 is identified as ent-gene-b2d5f914
ent-gene-b2d5f914 data_in benchmark_ot_ad_answer_key:ASC
benchmark_ot_ad_answer_key:ASC data_in ent-gene-b2d5f914

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