Contents

AQP4 (Aquaporin-4 Gene)

🧬 Gene Info

Gene Symbol	AQP4
Chromosome	18q11.2
Protein Family	Aquaporin (AQP) family
Target Class	Ion Channel
Mechanism of Action	Water channel inhibitor or modulator
Primary Expression	Astrocytes (perivascular endfeet), Ependyma, Kidney collecting duct
Subcellular Localization	Astrocyte end-feet, perivascular, ependymal
Druggability	Low (0.35)
Clinical Stage	Phase I
Molecular Weight	34 kDa
Amino Acids	323 aa
Pathways	Adaptive Immunity, Apoptosis, Blood-Brain Barrier, Chaperone, Glymphatic Pathway
UniProt ID	P55064
Ensembl ID	ENSG00000171885
GeneCards	AQP4
Human Protein Atlas	AQP4
Associated Diseases	neurodegeneration
Known Drugs/Compounds	TGN-020
SciDEX Target	View Target Profile (1 clinical trials)
SciDEX Hypotheses	SASP-Driven Aquaporin-4 Dysregulation Aquaporin-4 Polarization Rescue Loss of AQP4 Polarization Impairs Glymphatic Periv (+5 more)
KG Connections	1 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

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