| Gene Symbol | APBB1 |
| Full Name | amyloid beta precursor protein binding family B member 1 |
| Aliases | APBB1PROTEIN |
| Chromosome | 11p15.4 |
| Protein Type | Adaptor Protein |
| Function | APBB1 (Amyloid Precursor Protein Binding Family B Member 1), also known as Fe65, is a neuronal adaptor protein that plays critical roles in APP (Amyloid Precursor Protein) processing and signaling. |
| Primary Expression | the brain, particularly in: - Cerebral cortex (neurons) - Hippocampus (especially CA1 region) - |
| Subcellular Localization | directly impacts proteolytic processing, as it determines APP accessibility to secretases located in different membrane |
| Molecular Weight | 90 kDa |
| UniProt ID | [Q9UKP3](https://www.uniprot.org/uniprot/Q9UKP3) |
| Ensembl ID | ENSG00000196913 |
| OMIM | 602294 |
| GeneCards | APBB1 |
| Human Protein Atlas | APBB1 |
| APP (Amyloid Precursor Protein) | Primary binding partner and substrate |
| Associated Diseases | ALS, Diabetes, Hypertension |
| Interactions | Amyloid |
| KG Connections | 27 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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