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disease 1,334 words KG: ent-dise-c92709d0
Contents

Amyotrophic Lateral Sclerosis (ALS) Genetic Variants

Disease Info
Major causal genesC9orf72, SOD1, FUS, TARDBP (accounting for ~70% of familial ALS)
Moderate risk genesUBQLN2, OPTN, TBK1, VCP, ANG
GWAS-identified lociOver 15 risk loci identified through genome-wide studies
DatabasesOMIMOrphanetClinicalTrialsPubMed

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Knowledge Graph

Related Hypotheses (6)

Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.91Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78Stress Granule Phase Separation Modulators
Score: 0.72HDAC3-Selective Inhibition for Clock Reset
Score: 0.71TET2-Mediated Demethylation Rejuvenation Therapy
Score: 0.71Cryptic Exon Silencing Restoration
Score: 0.53

Related Analyses (3)

RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archivedEpigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archivedEpigenetic reprogramming in aging neurons
neurodegeneration · archived

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