| Gene Symbol | ent-gene-6db0dfd2 |
| Function | - Complex I assembly: Critical for proper assembly and stability of NADH:ubiquinone oxidoreductase (Complex I) |
| FAD-binding domain | Residues 150-400, binds FAD cofactor essential for NADH oxidase activity |
| DNA-binding domain | C-terminal region (residues 400-613) can bind DNA in the nucleus |
| Proline-rich region | Contains SH3-binding motifs for protein interactions |
| Complex I assembly | Critical for proper assembly and stability of NADH:ubiquinone oxidoreductase (Complex I) |
| NADH oxidation | Functions as a NADH oxidase using FAD as cofactor, contributing to mitochondrial redox balance |
| Mitochondrial DNA maintenance | Required for mitochondrial DNA (mtDNA) transcription and replication |
| Iron-sulfur cluster biogenesis | Involved in assembly of Fe-S clusters essential for multiple mitochondrial enzymes |
| Calpain cleavage | Ca²⁺-dependent calpains cleave AIF at residue 1025, releasing it from the inner membrane |
| Nuclear translocation | Cleaved AIF (tAIF, ~57 kDa) translocates to the nucleus in a PARP-1-dependent manner |
| DNA fragmentation | tAIF promotes large-scale DNA fragmentation (50 kb fragments) through chromatin condensation |
| Caspase-independent cell death | Mediates apoptosis even when caspase activity is blocked |
| Tissue distribution | Highest expression in heart, brain, skeletal muscle, and liver |
| Brain regions | Particularly high in neurons of the hippocampus, cerebral cortex, and basal ganglia |
| Cellular localization | Mitochondrial inner membrane (primarily), with nuclear translocation during apoptosis |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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