| Gene Symbol | ent-gene-80a0f518 |
| Function | ### Circadian Rhythm Regulation |
| N-terminal extracellular domain | Ligand binding site |
| Seven transmembrane helices | G-protein coupling domains |
| C-terminal intracellular domain | Phosphorylation sites for receptor desensitization |
| Disulfide bonds | Conserved cysteine residues for structural stability |
| Melatonin | Primary endogenous ligand (Kj ~ 10-100 pM) |
| Agomelatine | Synthetic agonist (used for depression) |
| Ramelteon | Synthetic agonist (used for insomnia) |
| Luzindole | Selective antagonist |
| Suprachiasmatic Nucleus (SCN) | Highest density, circadian pacemaker |
| Hippocampus | CA1-CA3 regions, dentate gyrus |
| Cerebral cortex | All cortical layers, particularly layer 6 |
| Basal forebrain | Cholinergic neurons |
| Paraventricular nucleus | Autonomic regulation |
| Area postrema | Nausea/vomiting reflex |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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