SciDEX — Task: [Exchange] Full enrichment batch 4

Full enrichment for: NAD+ Depletion Rescue (h-cb833ed8), P2Y12 Inverse Agonist (h-f99ce4ca), C1q Mimetic Decoy (h-1fe4ba9b), Lysyl Oxidase Inhibition (h-82922df8), PARP1 Inhibition (h-69919c49). Each gets pathway diagram, clinical trials, gene expression context. ## REOPENED TASK — CRITICAL CONTEXT This task was previously marked 'done' but the audit could not verify the work actually landed on main. The original work may have been: - Lost to an orphan branch / failed push - Only a spec-file edit (no code changes) - Already addressed by other agents in the meantime - Made obsolete by subsequent work **Before doing anything else:** 1. **Re-evaluate the task in light of CURRENT main state.** Read the spec and the relevant files on origin/main NOW. The original task may have been written against a state of the code that no longer exists. 2. **Verify the task still advances SciDEX's aims.** If the system has evolved past the need for this work (different architecture, different priorities), close the task with reason "obsolete: " instead of doing it. 3. **Check if it's already done.** Run `git log --grep=''` and read the related commits. If real work landed, complete the task with `--no-sha-check --summary 'Already done in '`. 4. **Make sure your changes don't regress recent functionality.** Many agents have been working on this codebase. Before committing, run `git log --since='24 hours ago' -- ` to see what changed in your area, and verify you don't undo any of it. 5. **Stay scoped.** Only do what this specific task asks for. Do not refactor, do not "fix" unrelated issues, do not add features that weren't requested. Scope creep at this point is regression risk. If you cannot do this task safely (because it would regress, conflict with current direction, or the requirements no longer apply), escalate via `orchestra escalate` with a clear explanation instead of committing.

Completion Notes

Auto-completed by supervisor after successful deploy to main

Git Commits (4)

[Verify] Full enrichment batch 4 already resolved — all 5 hypotheses have pathway diagrams, clinical trials, gene expression [task:88e25c11-8f65-49e8-a4c4-ec4432a18ccf]2026-04-20

Spec File

[Exchange] Full enrichment batch 4 — pathway diagrams, clinical trials, gene expression for 5 more hypotheses

ID: 88e25c11-8f6 Priority: 88 Type: one_shot Status: open

Goal

Acceptance Criteria

☐ Concrete deliverables created

☐ Work log updated with timestamped entry

Work Log

2026-04-20 23:30 UTC — Verification pass

Ran DB query against PostgreSQL hypotheses table for all 5 target IDs
Confirmed all 5 hypotheses already have all 3 enrichment types populated:

- h-cb833ed8 (NAD+ Depletion Rescue / CD38/NAMPT): pathway=2051chars, trials=3500chars, gex=1534chars ✓
- h-f99ce4ca (P2Y12 Inverse Agonist / P2RY12): pathway=1045chars, trials=7427chars, gex=1746chars ✓
- h-1fe4ba9b (C1q Mimetic Decoy / C1QA): pathway=2069chars, trials=7330chars, gex=746chars ✓
- h-82922df8 (Lysyl Oxidase Inhibition / LOX/LOXL1-4): pathway=1373chars, trials=1192chars, gex=824chars ✓
- h-69919c49 (PARP1 Inhibition / PARP1): pathway=842chars, trials=3845chars, gex=676chars ✓

All enrichment types are substantive (>200 chars pathway, >100 chars trials, >100 chars gene expression)
Evidence: Direct PostgreSQL query via scidex.core.database.get_db()
Result: Already resolved on main — prior enrichment batch work covered these hypotheses

Already Resolved — 2026-04-20 23:30:00Z

All 5 hypotheses verified populated on main via direct DB query.
No code changes needed; task closes as pass.

Payload JSON

{
  "requirements": {
    "coding": 7,
    "reasoning": 7,
    "analysis": 8
  },
  "completion_shas": [
    "aa4f29536"
  ],
  "completion_shas_checked_at": "2026-04-20T23:03:52.378064+00:00"
}