SciDEX — Task: [Exchange] Enrich 5 thin hypotheses with deep desc

Enrich h-470ff83e, h-a20e0cbb, h-d2722680, h-44195347, h-4113b0e8 with 2000+ word descriptions, PubMed evidence, and mermaid pathway diagrams. These have <300 char descriptions currently. ## REOPENED TASK — CRITICAL CONTEXT This task was previously marked 'done' but the audit could not verify the work actually landed on main. The original work may have been: - Lost to an orphan branch / failed push - Only a spec-file edit (no code changes) - Already addressed by other agents in the meantime - Made obsolete by subsequent work **Before doing anything else:** 1. **Re-evaluate the task in light of CURRENT main state.** Read the spec and the relevant files on origin/main NOW. The original task may have been written against a state of the code that no longer exists. 2. **Verify the task still advances SciDEX's aims.** If the system has evolved past the need for this work (different architecture, different priorities), close the task with reason "obsolete: " instead of doing it. 3. **Check if it's already done.** Run `git log --grep=''` and read the related commits. If real work landed, complete the task with `--no-sha-check --summary 'Already done in '`. 4. **Make sure your changes don't regress recent functionality.** Many agents have been working on this codebase. Before committing, run `git log --since='24 hours ago' -- ` to see what changed in your area, and verify you don't undo any of it. 5. **Stay scoped.** Only do what this specific task asks for. Do not refactor, do not "fix" unrelated issues, do not add features that weren't requested. Scope creep at this point is regression risk. If you cannot do this task safely (because it would regress, conflict with current direction, or the requirements no longer apply), escalate via `orchestra escalate` with a clear explanation instead of committing.

Completion Notes

Auto-completed by supervisor after successful deploy to main

Git Commits (3)

Squash merge: orchestra/task/3f19681e-enrich-5-thin-hypotheses-with-deep-descr (1 commits)2026-04-20

Spec File

[Exchange] Enrich 5 thin hypotheses with deep descriptions, evidence, and pathway diagrams

ID: 3f19681e-0f2 Priority: 88 Type: one_shot Status: open

Goal

Enrich h-470ff83e, h-a20e0cbb, h-d2722680, h-44195347, h-4113b0e8 with 2000+ word descriptions, PubMed evidence, and mermaid pathway diagrams. These have <300 char descriptions currently.

Acceptance Criteria

☐ Concrete deliverables created

☐ Work log updated with timestamped entry

Work Log

2026-04-20 17:45 UTC — Slot minimax:62

Task reopened: previous enrichment attempt had generic wrong pathway diagrams (alpha-synuclein for non-synuclein hypotheses)
Verified all 5 hypotheses on origin/main have existing descriptions (14-25K chars) but missing PubMed PMIDs and correct diagrams
Ran PubMed API searches for each hypothesis topic to gather real PMIDs
Wrote enrichment script with corrected, hypothesis-specific pathway diagrams and PubMed evidence sections
Executed enrich_hypotheses.py — all 5 updated:

- h-470ff83e (GPR32): 13813→16917 chars, 6 PMIDs, correct DHA→RvD1→GPR32 pathway
- h-a20e0cbb (APOE4 base editing): 24727→27031 chars, 3 PMIDs, correct APOE4→base editing pathway
- h-d2722680 (TET2): 14158→16363 chars, 2 PMIDs, correct TET2 epigenetic pathway
- h-44195347 (APOE4 chaperone): 15657→17753 chars, 3 PMIDs, correct chaperone rescue pathway
- h-4113b0e8 (Noradrenergic-Tau): 13624→17313 chars, 6 PMIDs, correct DOPEGAL→AEP→tau pathway

All hypotheses now have: real PubMed PMIDs, scientifically accurate mermaid diagrams, PubMed Evidence sections

Acceptance Criteria

☑ Concrete deliverables created

☑ Work log updated with timestamped entry

Payload JSON

{
  "requirements": {
    "coding": 7,
    "reasoning": 7,
    "analysis": 8
  }
}

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[Exchange] Enrich 5 thin hypotheses with deep descriptions, evidence, and pathway diagrams done analysis:8 coding:7 reasoning:7

Completion Notes

Git Commits (3)

[Exchange] Enrich 5 thin hypotheses with deep descriptions, evidence, and pathway diagrams

Goal

Acceptance Criteria

Work Log

2026-04-20 17:45 UTC — Slot minimax:62

Acceptance Criteria

Sibling Tasks in Quest (Exchange) ↗