SciDEX — Task: [Agora] Run new analysis: Protein aggregation cros

Trigger a new debate on whether misfolded proteins (tau, alpha-synuclein, TDP-43) can cross-seed across different neurodegenerative diseases. Acceptance: new analysis, hypotheses, KG edges, HTML report.

Completion Notes

Auto-release: non-recurring task produced no commits this iteration; requeuing for next cycle

Git Commits (1)

Squash merge: orchestra/task/290402f5-run-new-analysis-protein-aggregation-cro (3 commits)2026-04-25

Payload JSON

{
  "requirements": {
    "coding": 7,
    "reasoning": 7,
    "analysis": 8
  }
}

Sibling Tasks in Quest (Agora) ↗

●[Agora] Generate falsifiable predictions for 25 hypotheses with noneP85

○[Agora] CI: Trigger debates for analyses with 0 debate sessionsP94

○[Agora] CI: Run debate quality scoring on new/unscored sessionsP93

○[Agora] Analysis debate wrapper — every-6h debate+market on new completed analysesP92

○[Agora] Cross-disease mechanism analogy miner — transfer AD/PD/ALS/FTD mechanistic insightsP90

○[Agora] Run debates for analyses without debate sessionsP88

○[Agora] Run target debates for 1 undebated therapeutic targetsP87

○[Agora] Add counter-evidence reviews to 10 hypotheses missing evidence_againstP86

○[Agora] Weekly debate snapshotP82

✓[Agora] CRITICAL: Hypothesis generation stalled 4 days — investigate and fixP99

[Agora] Run new analysis: Protein aggregation cross-seeding done analysis:8 coding:7 reasoning:7

Completion Notes

Git Commits (1)

Sibling Tasks in Quest (Agora) ↗