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🎯 Drug Targets

Browse 7 drug targets with druggability analysis, composite scores, and clinical context

7
Targets
0
High Druggability
0.54
Avg Score
15
Target Classes
Druggability Distribution
High: 0Medium: 0Low: 7Unknown: 0
Avg druggability score: 0.383
Clinical Pipeline
Approved: 3Phase III: 1Phase II: 1Phase I: 2Preclinical: 0
Total compounds: 17 · Approved: 4
Class All Classes Enzyme (35) Signaling Protein (25) Structural Protein (17) Protein (16) Gpcr (13) Ion Channel (12) Receptor (11) Transcription Factor (11) Ligand (10) Epigenetic Regulator (8) Transporter (8) Kinase (7) Other (4) Protease (4) Chaperone (4)
Druggability All Druggability Low (97) Medium (56) Undruggable (19) High (10) other (3)
Sort Score Druggability Gene A-Z Market Price
Filtered by: class=transcription_factor, druggability=Low — 7 results
PPARGC1A Peroxisome proliferator-activated receptor gamma c Approved
Transcription Factor Low Druggability
Score
0.57
Drug.
0.43
Safety
0.40
Drugs
3
Hyps
3
Papers
49
Small molecule modulator of transcriptional coactivator function
FOXO3 Forkhead box protein O3 Approved
Transcription Factor Low Druggability
Score
0.56
Drug.
0.42
Safety
0.35
Drugs
4
Hyps
3
Papers
36
FOXO3-targeting drugs modulate the PI3K/Akt/FOXO3 signaling pathway to promote FOXO3 nuclear translocation and transcriptional activity, enhancing autophagy, stress resistance, and apoptosis in cancer cells. Indirect activators increase FOXO3 expression or prevent its degradation, thereby amplifying cellular protective responses.
CLOCK Circadian Locomotor Output Cycles Kaput Approved
Transcription Factor Low Druggability
Score
0.55
Drug.
0.35
Safety
0.40
Drugs
1
Hyps
14
Papers
81
Modulation of circadian transcriptional activity through protein-protein interaction disruption
BMAL1 Basic Helix-Loop-Helix ARNT Like 1 Phase I
Transcription Factor Low Druggability
Score
0.54
Drug.
0.34
Safety
0.30
Drugs
4
Hyps
11
Papers
29
Small molecule modulator of circadian transcription
AHR Aryl hydrocarbon receptor Phase II
Transcription Factor Low Druggability
Score
0.54
Drug.
0.35
Safety
0.40
Drugs
2
Hyps
4
Papers
0
Small molecule modulators affecting ligand-dependent transcriptional activity
TARDBP TAR DNA-binding protein 43 Phase III
Transcription Factor Low Druggability
Score
0.51
Drug.
0.43
Safety
0.20
Drugs
1
Hyps
6
Papers
57
RNA-binding and transcription regulation, challenging for small molecule targeting
FOXP3 Forkhead box protein P3 Phase I
Transcription Factor Low Druggability
Score
0.50
Drug.
0.35
Safety
0.30
Drugs
2
Hyps
1
Papers
18
Transcription factor modulation - no direct small molecule binding
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