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🎯 Drug Targets

Browse 3 drug targets with druggability analysis, composite scores, and clinical context

3
Targets
3
High Druggability
0.70
Avg Score
15
Target Classes
Druggability Distribution
High: 3Medium: 0Low: 0Unknown: 0
Avg druggability score: 0.867
Clinical Pipeline
Approved: 2Phase III: 0Phase II: 1Phase I: 0Preclinical: 0
Total compounds: 8 · Approved: 4
Class All Classes Enzyme (35) Signaling Protein (25) Structural Protein (17) Protein (16) Gpcr (13) Ion Channel (12) Receptor (11) Transcription Factor (11) Ligand (10) Epigenetic Regulator (8) Transporter (8) Kinase (7) Other (4) Protease (4) Chaperone (4)
Druggability All Druggability Low (97) Medium (56) Undruggable (19) High (10) other (3)
Sort Score Druggability Gene A-Z Market Price
Filtered by: class=ion_channel, druggability=High — 3 results
GABRA1 Gamma-aminobutyric acid receptor subunit alpha-1 Approved
Ion Channel High Druggability
Score
0.72
Drug.
0.90
Safety
0.60
Drugs
4
Hyps
2
Papers
32
GABRA1 mediates inhibitory neurotransmission through GABA-A receptor subunit composition, modulating neuronal excitability and synaptic signaling. In neurodegeneration contexts, alterations in GABRA1 expression or function can contribute to neuronal hyperexcitability, oxidative stress, and potentially accelerated cellular damage mechanisms associated with progressive neurological disorders.
CACNA1G Voltage-dependent T-type calcium channel subunit a Approved
Ion Channel High Druggability
Score
0.70
Drug.
0.90
Safety
0.60
Drugs
2
Hyps
1
Papers
31
Small molecule blocker of T-type calcium channel activity
P2RX7 P2X purinoreceptor 7 Phase II
Ion Channel High Druggability
Score
0.68
Drug.
0.80
Safety
0.60
Drugs
2
Hyps
1
Papers
29
Selective P2X7 receptor antagonists blocking ATP-gated ion channel
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