[Exchange] Enrich hypotheses 4-10 with deep descriptions
Goal
Enrich the top-ranked hypotheses (positions 4-10) on the Exchange with comprehensive scientific descriptions to improve their value for researchers. Each hypothesis should have a detailed mechanistic explanation (1000+ words), evidence chains showing causal relationships, and at least 5 verified PubMed citations supporting the mechanism. This elevates the Exchange from a scoring system to a knowledge repository.
Target Hypotheses (Ranked 4-10)
Based on task description:
CYP46A1
Membrane Cholesterol
SASP Complement
AMPK Astrocytes
Autophagy-Lysosome
TREM2 Tau Clearance
Circadian MelatoninAcceptance Criteria
☐ All 7 hypotheses identified in the database
☐ Each hypothesis has 1000+ word description with mechanistic details
☐ Each hypothesis has 5+ verified PubMed citations (PMIDs)
☐ Evidence chains documented (cause → mechanism → effect)
☐ Database fields updated (description, evidence_for, citations)
☐ All hypothesis pages load correctly (HTTP 200)
☐ Changes committed with clear message
☐ Task marked complete in Orchestra
Approach
Query PostgreSQL to identify hypotheses ranked 4-10
For each hypothesis:
- Research the biological mechanism in detail
- Write comprehensive description (1000+ words) covering:
- Molecular mechanism
- Cellular pathways involved
- Connection to neurodegenerative disease
- Evidence supporting the hypothesis
- Therapeutic implications
- Find 5+ relevant PubMed citations
- Document evidence chain (upstream → hypothesis → downstream)
Update database with enriched content
Test hypothesis pages render correctly
Commit and mark completeWork Log
2026-04-02 09:48 UTC — Slot 4
- Started task: Enrich hypotheses 4-10 with deep descriptions
- Creating spec file following AGENTS.md format
2026-04-18 — Task Reset After PG Migration
- Prior enrichment work (task 82243992) was done on SQLite; migrated to PostgreSQL on 2026-04-17
- Checked current state: 3/7 hypotheses already enriched (Membrane Cholesterol 10 PMIDs, SASP Complement 10 PMIDs, CYP46A1 4 PMIDs)
- 4 hypotheses had descriptions (1200-3000+ words) but 0 explicit PMID citations
- Ran
scripts/enrich_hypotheses_pmids.py to add evidence sections with PubMed citations:
- CYP46A1 (h-2600483e): 4→7 PMIDs, 1438→1570 words
- AMPK Astrocytes (h-43f72e21): 0→12 PMIDs, 1373→1905 words
- Autophagy-Lysosome (h-ae1b2beb): 0→9 PMIDs, 1272→1777 words
- TREM2 Tau Clearance (SDA-...H002): 0→11 PMIDs, 1217→1795 words
- Circadian Proteostasis (h-0e0cc0c1): 0→14 PMIDs, 3073→3709 words
- All 7 hypothesis pages verified: HTTP 200
- Result: All 7 hypotheses now have 1000+ words, 5+ PMIDs, evidence chains with mechanism details