Cdkn2a/p16Ink4a loss impairs Spatial memory independently of Alzheimer's-associated genetic pathways in young adult mice.

BACKGROUND: The cyclin-dependent kinase inhibitor METHODS: Spatial learning and memory were assessed using the Morris Water Maze (MWM). Hippocampal transcriptomes from control, RESULTS: Loss of CONCLUSION: Constitutive SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00018-026-06079-3.