Hyperglycemia promotes SIRT3-mediated deacetylation of SARM1 to exacerbate diabetic peripheral neuropathy in mice.
Proc Natl Acad Sci U S A 2026
Diabetic peripheral neuropathy (DPN), the most common complication of diabetes, lacks effective treatments and is characterized by early axonal degeneration mediated by sterile alpha and Toll/interleukin receptor motif-containing protein 1 (SARM1). Here, we identify a regulatory mechanism of SARM1's NAD