Cardiomyocyte-derived calcitonin regulates atrial fibrosis and AF.
Fernández-Ruiz I
Nature reviews. Cardiology 2021
Comprehensive analysis of CRISPR off-target editing in neural tissues reveals higher rates of unintended modifications in post-mitotic neurons compared to dividing cells. Off-target effects persist permanently in non-dividing cells, raising significant safety concerns for CNS applications.