Emerging role of 12/15-Lipoxygenase (ALOX15) in human pathologies.

1. Prog Lipid Res. 2019 Jan;73:28-45. doi: 10.1016/j.plipres.2018.11.001. Epub 2018 Nov 22. Emerging role of 12/15-Lipoxygenase (ALOX15) in human pathologies. Singh NK(1), Rao GN(2). Author information: (1)Department of Physiology, University of Tennessee Health Science Center, 71 S. Manassas Street Memphis, Memphis, TN 38163, USA. (2)Department of Physiology, University of Tennessee Health Science Center, 71 S. Manassas Street Memphis, Memphis, TN 38163, USA. Electronic address: rgadipar@uthsc.edu. 12/15-lipoxygenase (12/15-LOX) is an enzyme, which oxidizes polyunsaturated fatty acids, particularly omega-6 and -3 fatty acids, to generate a number of bioactive lipid metabolites. A large number of studies have revealed the importance of 12/15-LOX role in oxidative and inflammatory responses. The in vitro studies have demonstrated the ability of 12/15-LOX metabolites in the expression of various genes and production of cytokine related to inflammation and resolution of inflammation. The studies with the use of knockout and transgenic animals for 12/15-LOX have further shown its involvement in the pathogenesis of a variety of human diseases, including cardiovascular, renal, neurological and metabolic disorders. This review summarizes our current knowledge on the role of 12/15-LOX in inflammation and various human diseases. Copyright © 2018 Elsevier Ltd. All rights reserved. DOI: 10.1016/j.plipres.2018.11.001 PMCID: PMC6338518 PMID: 30472260 [Indexed for MEDLINE]