Temperature sensitivity of two-pore (K2P) potassium channels.

Schneider ER, Anderson EO, Gracheva EO, Bagriantsev SN

Curr Top Membr 2014

1. Curr Top Membr. 2014;74:113-33. doi: 10.1016/B978-0-12-800181-3.00005-1. Temperature sensitivity of two-pore (K2P) potassium channels. Schneider ER(1), Anderson EO(1), Gracheva EO(2), Bagriantsev SN(1). Author information: (1)Department of Cellular & Molecular Physiology, Yale School of Medicine, New Haven, CT, USA. (2)Department of Cellular & Molecular Physiology, Yale School of Medicine, New Haven, CT, USA; Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale School of Medicine, New Haven, CT, USA. At normal body temperature, the two-pore potassium channels TREK-1 (K2P2.1/KCNK2), TREK-2 (K2P10.1/KCNK10), and TRAAK (K2P4.1/KCNK2) regulate cellular excitability by providing voltage-independent leak of potassium. Heat dramatically potentiates K2P channel activity and further affects excitation. This review focuses on the current understanding of the physiological role of heat-activated K2P current, and discusses the molecular mechanism of temperature gating in TREK-1, TREK-2, and TRAAK. DOI: 10.1016/B978-0-12-800181-3.00005-1 PMCID: PMC4794111 PMID: 25366235 [Indexed for MEDLINE]

1 Figure Extracted

Figures Deep Link

Figures available at source paper (no open-access XML found).

View on publisher site →