The lure of a LYR: The logistics of iron sulfur cluster delivery.
["Lane, D J R", "Merlot, A M", "Richardson, D R"]
Cell metabolism 2014
How are nascent iron-sulfur (Fe-S) clusters directed to specific recipient proteins? In this issue of Cell Metabolism, Maio et al. (2014) show that the mitochondrial Fe-S cochaperone protein HSC20 guides nascent Fe-S clusters based on a highly conserved motif, LYR, that exists in target proteins in different molecular contexts.