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Mechanistic role of APOE in neurodegeneration — Analysis Notebook

CI-generated notebook stub for analysis sda-2026-04-01-gap-auto-fd6b1635d9. Mechanistic role of APOE in neurodegeneration?

📊 Related Analysis: Mechanistic role of APOE in neurodegeneration (neurodegeneration)

Notebook Overview

Cells
13
Markdown
7
Code
6
Executed
6
Output Cells
6
Kernel
Python 3
Language
python 3.13.12
Notebook
v4.5
Created: 2026-04-16
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Notebook Outline

Mechanistic Role of APOE in Neurodegeneration1. APOE Allele Frequencies Across Neurodegenerative Diseases2. APOE4 Relative Risk by Disease3. APOE Mechanistic Pathways Table4. APOE4 vs APOE3 Structural Differences and Functional Consequences5. APOE Genotype Gene-Dose EffectsConclusions and Therapeutic Implications

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MarkdownMechanistic Role of APOE in NeurodegenerationCodeimport numpy as npIn [1]Markdown1. APOE Allele Frequencies Across Neurodegenerative DiseasesCodediseases = ['Control', 'AD', 'PD', 'LBD', 'FTD', 'ALS']In [2]Markdown2. APOE4 Relative Risk by DiseaseCode# Relative risk (OR) for APOE4 carriers (one copy) vs APOE3 homozygotesIn [3]Markdown3. APOE Mechanistic Pathways TableCodepathway_data = {In [4]Markdown4. APOE4 vs APOE3 Structural Differences and Functional ConsequencesCodetherapeutic_data = {In [5]Markdown5. APOE Genotype Gene-Dose EffectsCodegenotypes = ['E2/E2', 'E2/E3', 'E3/E3', 'E3/E4', 'E4/E4']In [6]MarkdownConclusions and Therapeutic Implications

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