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Neuroinflammation resolution mechanisms and pro-resolving mediators — Analysis Notebook

CI-generated notebook stub for analysis sda-2026-04-01-gap-014. SPMs (resolvins, protectins, maresins) from omega-3s may promote inflammation resolution. Are resolution failures druggable?

📊 Related Analysis: Neuroinflammation resolution mechanisms and pro-resolving mediators (neurodegeneration)

Notebook Overview

Cells
13
Markdown
7
Code
6
Executed
6
Output Cells
6
Kernel
Python 3
Language
python 3.13.12
Notebook
v4.5
Created: 2026-04-16
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Notebook Outline

Neuroinflammation Resolution Mechanisms and Pro-Resolving Mediators1. SPM Levels in AD vs PD vs Control Brains2. SPM Biosynthesis Pathway Table3. Resolution Index Heatmap by Brain Region4. Dose-Response Curves for Resolvins in Neuroinflammation Models5. Clinical-Stage Drug Targets for Resolution PharmacologyConclusions

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MarkdownNeuroinflammation Resolution Mechanisms and Pro-Resolving MediatorsCodeimport numpy as npIn [1]Markdown1. SPM Levels in AD vs PD vs Control BrainsCodespms = ['RvD1', 'RvD2', 'RvE1', 'NPD1', 'MaR1', 'LXA4', 'LXB4']In [2]Markdown2. SPM Biosynthesis Pathway TableCodebiosynthesis_data = {In [3]Markdown3. Resolution Index Heatmap by Brain RegionCodebrain_regions = ['Frontal\nCortex', 'Hippocampus', 'Entorhinal\nCortex', 'In [4]Markdown4. Dose-Response Curves for Resolvins in Neuroinflammation ModelsCode# Dose-response Hill equation: E = Emax * C^n / (EC50^n + C^n)In [5]Markdown5. Clinical-Stage Drug Targets for Resolution PharmacologyCodedrug_targets_data = {In [6]MarkdownConclusions

💬 Discussion

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