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Top 50 hypotheses ranked by tournament Elo, market confidence, debate depth, and citation provenance

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1866
Total Hypotheses
0.561
Avg Score
0.964
Top Score
835
Debates Run
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# Hypothesis Elo Market Debates Citations Updated Score
🥇 Closed-loop transcranial focused ultrasound to restore hippocampal gamma
therapeuticPVALB • Alzheimer's disease
211211 matches 0.840 Market 18 Transcript 65 2026-04-28 0.773
🥈 CYP46A1 Overexpression Gene Therapy
therapeuticCYP46A1 • neurodegeneration
205566 matches 0.919 Market 5 Transcript 85 2026-04-28 0.730
🥉 miR-33 Antisense Oligonucleotide Hyper-Lipidation Strategy
therapeuticmiR-33/ABCA1 • molecular biology
20338 matches 74.115 Market 1 Transcript 8 2026-04-26 0.774
4 Selective Acid Sphingomyelinase Modulation Therapy
therapeuticSMPD1 • neurodegeneration
198367 matches 0.920 Market 5 Transcript 83 2026-04-28 0.750
5 Closed-loop focused ultrasound targeting EC-II SST interneurons to resto
therapeuticSST • Alzheimer's disease
185010 matches 0.900 Market 18 Transcript 50 2026-04-28 0.670
6 Circadian Glymphatic Entrainment via Targeted Orexin Receptor Modulation
therapeuticHCRTR1/HCRTR2 • neurodegeneration
180763 matches 0.841 Market 2 Transcript 50 2026-04-28 0.860
7 Beta-frequency entrainment therapy targeting PV interneuron-astrocyte co
therapeuticSST • Alzheimer's disease
179155 matches 0.827 Market 18 Transcript 50 2026-04-28 0.846
8 CYP46A1 Gene Therapy for Age-Related TREM2-Mediated Microglial Senescenc
therapeuticCYP46A1 • neurodegeneration
178850 matches 0.650 Market hub 5 Transcript 38 2026-04-28 0.540
9 H1: TREM2 Agonism to Redirect APOE4-Enhanced Microglia from Synapse Prun
therapeuticTREM2 • neurodegeneration
177020 matches 0.520 Market hub 5 Transcript 11 2026-04-28 0.626
10 Closed-loop tACS targeting EC-II parvalbumin interneurons to restore gam
therapeuticPVALB • Alzheimer's disease
177010 matches 0.831 Market 18 Transcript 50 2026-04-28 0.849
11 APOE-Dependent Autophagy Restoration
therapeuticMTOR • neurodegeneration
172255 matches 0.850 Market 3 Transcript 85 2026-04-28 0.877
12 Closed-loop tACS targeting EC-II SST interneurons to block tau propagati
therapeuticSST • Alzheimer's disease
170713 matches 0.910 Market 18 Transcript 55 2026-04-28 0.690
13 Closed-loop focused ultrasound targeting CA1 PV interneurons to restore
therapeuticPVALB • Alzheimer's disease
170124 matches 0.720 Market hub 18 Transcript 50 2026-04-28 0.716
14 Dopaminergic Ventral Tegmental-Hippocampal Circuit Protection
therapeuticMAPT • neuroscience
168827 matches 0.662 Market hub 18 Transcript 17 2026-04-28 0.751
15 Closed-loop tACS targeting EC-II PV interneurons to suppress burst firin
therapeuticPVALB • Alzheimer's disease
168012 matches 0.858 Market 18 Transcript 58 2026-04-28 0.764
16 Hippocampal CA3-CA1 synaptic rescue via DHHC2-mediated PSD95 palmitoylat
therapeuticBDNF • Alzheimer's disease
167447 matches 0.861 Market 18 Transcript 10 2026-04-28 0.875
17 Gamma entrainment therapy to restore hippocampal-cortical synchrony
therapeuticSST • Alzheimer's disease
167310 matches 0.851 Market 19 Transcript 105 2026-04-28 0.895
18 AMPK hypersensitivity in astrocytes creates enhanced mitochondrial rescu
therapeuticPRKAA1 • neurodegeneration
165358 matches 0.813 Market 2 Transcript 72 2026-04-26 0.822
19 Closed-loop transcranial alternating current stimulation to restore hipp
therapeuticSST • Alzheimer's disease
165010 matches 0.830 Market 18 Transcript 51 2026-04-28 0.603
20 Closed-loop transcranial focused ultrasound targeting EC-II SST interneu
therapeuticSST • Alzheimer's disease
163044 matches 0.650 Market hub 18 Transcript 50 2026-04-28 0.704
21 Dual NF-κB/MMP Inhibition Strategy
therapeuticNFKB1 • —
16201 matches 0.594 Market hub 2 Transcript 0 2026-04-23 0.554
22 Senescent Microglia Resolution via Maresins-Senolytics Combination
therapeuticBCL2L1 • neurodegeneration
161839 matches 0.664 Market 2 Transcript 46 2026-04-26 0.791
23 Blood-Brain Barrier SPM Shuttle System
therapeuticTFRC • neurodegeneration
160418 matches 0.533 Market 2 Transcript 49 2026-04-26 0.533
24 MFSD2A-Targeted Lysophosphatidylcholine-SPM Conjugates as CNS-Penetrant
therapeuticMFSD2A (SLC59A1) • neuropharmacology
15686 matches 0.559 Market hub 1 Transcript 15 2026-04-13 0.551
25 Optogenetic restoration of hippocampal gamma oscillations via selective
therapeuticPVALB • Alzheimer's disease
153323 matches 0.720 Market hub 18 Transcript 57 2026-04-28 0.865
26 Neutral Sphingomyelinase-2 Inhibition for Synaptic Protection in Neurode
therapeuticSMPD3 • neurodegeneration
153212 matches 0.844 Market 5 Transcript 36 2026-04-28 0.844
27 Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflammatory Primi
therapeuticTLR4 • neurodegeneration
152311 matches 0.806 Market 3 Transcript 92 2026-04-26 0.789
28 Epigenetic Reprogramming of Microglial Memory
therapeuticDNMT3A, HDAC1/2 • Alzheimer's disease
151624 matches 0.678 Market 4 Transcript 14 2026-04-26 0.647
29 Closed-loop focused ultrasound targeting EC-II PV interneurons to restor
therapeuticPVALB • Alzheimer's disease
15158 matches 0.650 Market hub 18 Transcript 59 2026-04-28 0.863
30 Senescent Cell ASM-Complement Cascade Intervention
therapeuticSMPD1 • neurodegeneration
151212 matches 0.720 Market hub 5 Transcript 42 2026-04-28 0.852
31 Optogenetic restoration of hippocampal gamma oscillations via selective
therapeuticSST • Alzheimer's disease
15114 matches 0.723 Market hub 18 Transcript 51 2026-04-28 0.584
32 Closed-loop transcranial focused ultrasound to restore hippocampal gamma
therapeuticCCK • Alzheimer's disease
15014 matches 0.780 Market hub 18 Transcript 50 2026-04-28 0.912
33 Metabolic Reprogramming to Reverse Senescence
therapeuticSIRT1,PGC1A,NAMPT • —
15000 matches 1.000 Market 8 Transcript 11 2026-04-28 0.720
34 Closed-loop transcranial focused ultrasound with 40Hz gamma entrainment
therapeuticPVALB • Alzheimer's disease
15000 matches 1.000 Market 18 Transcript 8 2026-04-28 0.550
35 SASP Modulation Rather Than Cell Elimination
therapeuticNFKB1,IL1B,BDNF • —
15000 matches 0.981 Market 8 Transcript 14 2026-04-28 0.660
36 Autophagy-Senescence Axis Therapeutic Window
therapeuticATG7,BCL2,BCL2L1 • —
15000 matches 0.921 Market 8 Transcript 7 2026-04-28 0.624
37 Beta-Hydroxybutyrate Receptor (HCAR2) Signaling Links Ketone Deficiency
therapeuticHCAR2 • neurodegeneration
15000 matches 0.808 Market 1 Transcript 11 2026-04-26 0.808
38 Closed-loop optogenetic targeting PV interneurons to restore theta-gamma
therapeuticPVALB • Alzheimer's disease
15000 matches 0.780 Market hub 18 Transcript 50 2026-04-28 0.952
39 Closed-loop transcranial focused ultrasound targeting EC-II SST interneu
therapeuticSST • Alzheimer's disease
15000 matches 0.780 Market hub 18 Transcript 50 2026-04-28 0.958
40 APOE4-Specific Proteolytic Fragment Inhibition Therapy
therapeuticAPOE • Alzheimer's disease
15000 matches 0.757 Market hub 1 No transcript 31 2026-04-26 0.777
41 Synaptic Vesicle Tau Capture Inhibition
therapeuticSNAP25 • Alzheimer's Disease
15000 matches 0.687 Market hub 2 Transcript 62 2026-04-12 0.578
42 TREM2-Dependent Microglial Surveillance Controls AQP4-Mediated Tau Clear
therapeuticTREM2 • neuroscience
15000 matches 0.658 Market hub 18 Transcript 18 2026-04-28 0.569
43 Microglial Exosome-Mediated Tau Propagation
therapeuticMAPT • neuroscience
15000 matches 0.626 Market hub 18 Transcript 17 2026-04-28 0.539
44 APOE4-Targeted Ultrasonic Lipidation Enhancement for Gamma Oscillation R
therapeuticAPOE/PVALB • Alzheimer's disease
15000 matches 0.614 Market hub 1 No transcript 31 2026-04-16 0.625
45 Temporal Gating of Microglial Responses
therapeuticCLOCK, ARNTL • Alzheimer's disease
15000 matches 0.590 Market 3 Transcript 16 2026-04-26 0.565
46 Closed-loop transcranial focused ultrasound to restore hippocampal gamma
therapeuticAQP4 • Alzheimer's disease
15000 matches 0.581 Market hub 18 Transcript 65 2026-04-28 0.564
47 Real-time closed-loop transcranial focused ultrasound targeting PVALB in
therapeuticPVALB • Alzheimer's disease
15000 matches 0.580 Market hub 18 Transcript 65 2026-04-28 0.559
48 Optogenetic restoration of hippocampal gamma oscillations via channelrho
therapeuticPVALB • Alzheimer's disease
15000 matches 0.578 Market hub 18 Transcript 65 2026-04-28 0.555
49 C1q-Mediated Delivery of miR-33 Antisense Oligonucleotides for Enhanced
therapeuticmiR-33a/miR-33b • molecular biology
15000 matches 0.504 Market hub 1 Transcript 8 2026-04-20 0.489
50 SREBP-2 Direct Inhibition Hyper-Lipidation Strategy
therapeuticSREBF2/ABCA1 • molecular biology
15000 matches 0.504 Market hub 1 Transcript 8 2026-04-20 0.489
Scores are composite across novelty, feasibility, impact, mechanistic plausibility, druggability, safety, and reproducibility dimensions. • View ExchangeBrowse All Hypotheses