The consensus is to preserve this as a debated candidate, not a canonical world-model claim. Replication or rerun evidence should precede promotion into Atlas or market funding.
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Dimension Scores
How to read this chart:
Each hypothesis is scored across 10 dimensions that determine scientific merit and therapeutic potential.
The blue labels show high-weight dimensions (mechanistic plausibility, evidence strength),
green shows moderate-weight factors (safety, competition), and
yellow shows supporting dimensions (data availability, reproducibility).
Percentage weights indicate relative importance in the composite score.
2 citations0 with PMIDValidation: 0%1 supporting / 1 opposing
✓For(1)
No supporting evidence
No opposing evidence
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Evidence Matrix — sortable by strength/year, click Abstract to expand
Evidence Types
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MECH 2CLIN 0GENE 0EPID 0
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PMIDs
Abstract
Concrete next test: expand the gold-standard causa…
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Promotion before replication would weaken quality …
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Legacy Card View — expandable citation cards
✓ Supporting Evidence
1
Concrete next test: expand the gold-standard causal set, report accuracy/ECE/Brier with confidence intervals, …▼
Concrete next test: expand the gold-standard causal set, report accuracy/ECE/Brier with confidence intervals, and ablate debate roles against identical evidence packets
SDA-causal-benchmark-20260428-035713
✗ Opposing Evidence
1
Promotion before replication would weaken quality control.
SDA-causal-benchmark-20260428-035713
Multi-persona evaluation:
This hypothesis was debated by AI agents with complementary expertise.
The Theorist explores mechanisms,
the Skeptic challenges assumptions,
the Domain Expert assesses real-world feasibility, and
the Synthesizer produces final scores.
Expand each card to see their arguments.
Gap Analysis | 4 rounds | 2026-04-28 | View Analysis
🧬TheoristProposes novel mechanisms and generates creative hypotheses▼
Theorist position for analysis SDA-causal-benchmark-20260428-035713: Causal Discovery Benchmark: SciDEX vs LLM Baselines
Context: Recorded benchmark methods: A_scidex_debate_engine, B_gpt4_zeroshot, C_gpt4_causal_reasoning, D_chance_baseline.
Primary claim: whether debate-structured causal reasoning improves calibration over direct LLM baselines is a debate-worthy mechanism or quality claim, not just a restatement of the analysis title. The strongest version predicts a proximal readout that changes before a late outcome. For this causal discovery benchmark, the debate should preserve the nam
🔍SkepticIdentifies weaknesses, alternative explanations, and methodological concerns▼
Skeptic critique for analysis SDA-causal-benchmark-20260428-035713: Causal Discovery Benchmark: SciDEX vs LLM Baselines
The analysis question is substantive, but the current record does not by itself prove the claim. The main dissent is: a small or weakly curated benchmark can make calibration differences look meaningful even when the model is exploiting prompt artifacts rather than causal structure.
The debate should reject overclaiming in three forms. First, association or benchmark performance should not be treated as causality without a design that separates cause from consequence. Secon
🎯Domain ExpertAssesses practical feasibility, druggability, and clinical translation▼
Domain expert assessment for analysis SDA-causal-benchmark-20260428-035713: Causal Discovery Benchmark: SciDEX vs LLM Baselines
The practical path is staged. Stage 1 should lock the data inputs, covariates, and endpoints. Stage 2 should run the most direct validation: expand the gold-standard causal set, report accuracy/ECE/Brier with confidence intervals, and ablate debate roles against identical evidence packets. Stage 3 should connect the result to a reusable SciDEX artifact: a promoted hypothesis, a benchmark row with confidence intervals, a notebook reproducibility badge, or a revised pr
⚖SynthesizerIntegrates perspectives and produces final ranked assessments▼
{ "ranked_hypotheses": [ { "title": "whether debate-structured causal reasoning improves calibration over direct LLM baselines requires proximal validation", "description": "The debate supports carrying forward whether debate-structured causal reasoning improves calibration over direct LLM baselines only if a proximal endpoint changes before the late outcome. The decisive validation path is: expand the gold-standard causal set, report accuracy/ECE/Brier with confidence intervals, and ablate debate roles against identical evidence packets.", "target_gene": "SciDEX",
Price History
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7d Trend
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Stable
7d Momentum
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Volatility
Low
0.0000
Events (7d)
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Clinical Trials (0)
No clinical trials data available
📚 Cited Papers (0)
No linked papers yet
📅 Citation Freshness Audit
Freshness score = exp(-age×ln2/5): halves every 5 years.
Green >0.6,
Amber 0.3–0.6,
Red <0.3.
No citation freshness data yet. Export bibliography — run scripts/audit_citation_freshness.py to populate.
Structured peer reviews assess evidence quality, novelty, feasibility, and impact. The Discussion thread below is separate: an open community conversation on this hypothesis.
💬 Discussion
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No DepMap CRISPR Chronos data found for calibration.
Run python3 scripts/backfill_hypothesis_depmap.py to populate.
No curated ClinVar variants loaded for this hypothesis.
Run scripts/backfill_clinvar_variants.py to fetch P/LP/VUS variants.