Move mammalian circuits from demonstrations to predictive, composable modules that can gate recording by cell state or exposure. Boundary domains: synthetic-biology, cell-engineering. Representative papers: Gene Digital Circuits Based on CRISPR-Cas Systems and Anti-CRISPR Proteins.; Programmable mammalian translational modulators by CRISPR-associated proteins.; A digital CRISPR-dCas9-based gene remodeling biocomputer programmed by dietary compounds in mammals.
Landscape Summary: Gap in Seattle Hub lineage tracing: Mammalian Synthetic Gene Circuits and Logic Gates is a 0.813 priority gap in synthetic-biology-lineage-tracing. It has 0 linked hypotheses with average composite score 0.000. Status: open.
Colonna, Sevlever, et al. (TREM2 biology)
Gap in Seattle Hub lineage tracing: Mammalian Synthetic Gene Circuits and Logic Gates — INVOKE-2 (completed)
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