The abstract identifies expression controllability as a major challenge, noting that reconfiguring excitatory and inhibitory properties in epilepsy is a delicate process requiring on-demand control. Current gene therapy lacks precise temporal and spatial expression control mechanisms. Gap type: open_question Source paper: Recent advances and current status of gene therapy for epilepsy. (2024, World journal of pediatrics : WJP, PMID:39395088)
Landscape Summary: How can gene therapy expression be precisely controlled on-demand for the delicate excitatory/inhibitory balance in epilepsy? is a 0.85 priority gap in neurotherapeutics. It has 0 linked hypotheses with average composite score 0.000. Status: open.
Colonna, Sevlever, et al. (TREM2 biology)
How can gene therapy expression be precisely controlled on-demand for the delicate excitatory/inhibitory balance in epilepsy? — INVOKE-2 (completed)
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