Mapping genetic disease risk (GWAS loci) to specific brain cell types using single-cell expression data. Includes MAGMA-cell, LDSC-SEG, and single-cell Mendelian randomization approaches for neuropsychiatric and neurodegenerative diseases. | Gap: Cell-type enrichment results vary across methods; fine-mapping to causal cell types is inconclusive; rare variant cell-type effects are largely unexplored.
Landscape Summary: [landscape-gap] GWAS & Genetic Cell Type Enrichment: Cell-type enrichment results vary across methods; fine-mapping to causal cell types is inconclusive; rare variant cell-type effects are largely unexplored. is a 0.8 priority gap in human-brain-cell-types. It has 0 linked hypotheses with average composite score 0.000. Status: open.
Colonna, Sevlever, et al. (TREM2 biology)
[landscape-gap] GWAS & Genetic Cell Type Enrichment: Cell-type enrichment results vary across methods; fine-mapping to causal cell types is inconclusive; rare variant cell-type effects are largely unexplored. — INVOKE-2 (completed)
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