Can lysosomal membrane stabilizers selectively prevent tau seeding without disrupting normal autophagy?

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While tau-induced lysosomal damage promotes seeding, the therapeutic hypothesis assumes membrane stabilization won't impair essential lysosomal dynamics. This selectivity has not been demonstrated experimentally. Source: Debate session sess_SDA-2026-04-03-gap-tau-prop-20260402003221 (Analysis: SDA-2026-04-03-gap-tau-prop-20260402003221)

Priority: 0.70 Domain: cell biology Hypotheses: 0

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Landscape Summary: Can lysosomal membrane stabilizers selectively prevent tau seeding without disrupting normal autophagy? is a 0.7 priority gap in cell biology. It has 0 linked hypotheses with average composite score 0.000. Status: open.

Key Unanswered Questions

What is the optimal TREM2 modulation strategy across disease stages?
How does DAM activation state affect therapeutic outcomes?
What biomarkers predict response to TREM2-targeted interventions?

Key Researchers

Colonna, Sevlever, et al. (TREM2 biology)

Clinical Trials

Can lysosomal membrane stabilizers selectively prevent tau seeding without disrupting normal autophagy? — INVOKE-2 (completed)

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