Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about tunneling nanotube: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| mitochondrial transfer | mediates | process | 0.85 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| GAP43-mediated tunneling nanotube stabilization enhances neu | 0.666 | neurodegeneration | Mitochondrial transfer between astrocyte |
| Modulating Tunneling Nanotube (TNT) Formation via M-Sec/Nora | 0.530 | neuroscience | Trans-synaptic tau spreading and propaga |
| M-Sec/TNTA2-mediated tunneling nanotube formation drives gli | 0.520 | neurodegeneration | Which tau propagation mechanism predomin |
Scientific analyses that reference this entity
cell biology | 2026-04-12 | 2 hypotheses Top: 0.724
neurodegeneration | 2026-04-07 | 6 hypotheses Top: 0.740
neuroscience | 2026-04-04 | 9 hypotheses Top: 0.772
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Proposed experiment from debate on Mitochondrial transfer between astr | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $100,000 |
| Axonal Transport Dysfunction Validation in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Gap Junction Dysfunction Validation in Parkinson's Disease | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Selective Neuronal Vulnerability to Aging — Mapping Why Specific Neuro | validation | Neurodegeneration | 0.400 | 0.50 | human | proposed | $3,000,000 |
| Synaptic Mitochondrial Resilience Enhancement for Parkinson's Disease | validation | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $2,730,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Calcium-Associated Proteins in Neuroregeneration. [PMID:38397420] | Lisek M, Tomczak J, Boczek T, Zylinska L | Biomolecules | 2024 | 1 |
| Selective inhibition of cannabinoid CB(1) receptor-evoked signalling by the inte [PMID:37689260] | Maroto IB, Moreno E, Costas-Insua C, Mer | Neuropharmacology | 2023 | 1 |
| lncRNA LOC100911717-targeting GAP43-mediated sympathetic remodeling after myocar [PMID:36684596] | Li P, Wang K, Yin J, Qi L, Hu H, Yang P, | Front Cardiovasc Med | 2022 | 1 |
| Machine Learning and Novel Biomarkers for the Diagnosis of Alzheimer's Disease. [PMID:33803217] | Chang CH, Lin CH, Lane HY | Int J Mol Sci | 2021 | 1 |
| Nerve growth cone motility. [PMID:2139335] | Lankford K, Cypher C, Letourneau P | Curr Opin Cell Biol | 1990 | 1 |
| The synergistic effects of UV-328 and polystyrene microplastics on zebrafish emb [PMID:41771220] | Yang X, Liao X, Zhong L, Lin M, Zhang M | Aquat Toxicol | 2026 | 0 |
| Biomarkers of synaptic degeneration in Alzheimer's disease. [PMID:39701184] | Cheng Q, Fan Y, Zhang P, Liu H, Han J, Y | Ageing research reviews | 2025 | 0 |
| Neurodegeneration and glial activation related blood biomarkers in Alzheimer's d [PMID:41242663] | Ebrahimi R, Salehi Amniyeh Khozani AA, M | Experimental gerontology | 2025 | 0 |
| Salidroside facilitates neuroprotective effects in ischemic stroke by promoting [PMID:39550919] | ["Lai W", "He Y", "Zhou B", "Wu Q", "Wu | Phytomedicine : international | 2024 | 0 |
| GAP43-dependent mitochondria transfer from astrocytes enhances glioblastoma tumo [PMID:37169842] | ["Watson D", "Bayik D", "Storevik S", "M | Nature cancer | 2023 | 0 |
| KHSRP loss increases neuronal growth and synaptic transmission and alters memory [PMID:35798971] | Olguin SL, Patel P, Buchanan CN, Dell'Or | Communications biology | 2022 | 0 |
| Accuracy of verbal fluency tests in the discrimination of mild cognitive impairm [PMID:31822214] | ["Garc\u00eda-Herranz S", "D\u00edaz-Mar | Neuropsychology, development, | 2020 | 0 |
| High incidence of progressive stenosis in aberrant left subclavian artery with r [PMID:28965152] | ["Muraoka M", "Nagata H", "Hirata Y", "U | Heart and vessels | 2018 | 0 |
| Serine Racemase and D-serine in the Amygdala Are Dynamically Involved in Fear Le [PMID:29025687] | ["Balu D", "Presti K", "Huang C", "Muszy | Biological psychiatry | 2018 | 0 |
| SNPs in microRNA target sites and their potential role in human disease. [PMID:28381629] | ["Moszy\u0144ska A", "Gebert M", "Collaw | Open biology | 2017 | 0 |
| Optical coherence tomography manifestations of primary vitreoretinal lymphoma. [PMID:27251192] | ["Saito T", "Ohguro N", "Iwahashi C", "H | Graefe's archive for clinical | 2016 | 0 |
| Quantifying targets for the SDG health goal. [PMID:25242036] | George Alleyne; Robert Beaglehole; Ruth | Lancet (London, England) | 2015 | 0 |
| SUMO1 promotes Aβ production via the modulation of autophagy. [PMID:25484073] | ["Cho S", "Yun S", "Jo C", "Lee D", "Cho | Autophagy | 2015 | 0 |
| Future Expectations of Diagnostic Approaches for Treating Endogenous Peritonitis [PMID:24633044] | Mizuno Masashi; Suzuki Yasuhiro; Ito Yas | Internal Medicine | 2014 | 0 |
| Liver gene transfer of interkeukin-15 constructs that become part of circulating [PMID:23285013] | ["Ochoa M", "Fioravanti J", "Duitman E", | PloS one | 2012 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.34 · 2026-04-27
closed · Rounds: 4 · Score: 0.78 · 2026-04-22
closed · Rounds: 4 · Score: 0.66 · 2026-04-21
closed · Rounds: 4 · Score: 0.74 · 2026-04-12
Hypotheses and analyses mentioning tunneling nanotube in their description or question text
No additional research found