Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about tight-junction remodeling: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No AI portrait yet
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| h-gap-5c6cec3e-m1 | involves | hypothesis | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| tight-junction remodeling is the actionable driver in: Blood | 0.362 | neurodegeneration | Blood-brain barrier permeability changes |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-26 | 3 hypotheses Top: 0.362
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Blood-brain barrier biomarkers. [PMID:38797540] | Zapata-Acevedo JF, Mantilla-Galindo A, V | Adv Clin Chem | 2024 | 0 |
| Endothelial Cell Senescence Effect on the Blood-Brain Barrier in Stroke and Cogn [PMID:39541552] | Real MGC, Falcione SR, Boghozian R | Neurology | 2024 | 0 |
| Blood-brain barrier biomarkers. [PMID:38797540] | Zapata-Acevedo JF, Mantilla-Galindo A, V | Advances in clinical chemistry | 2024 | 0 |
| Endothelial Cell Senescence Effect on the Blood-Brain Barrier in Stroke and Cogn [PMID:39541552] | ["Real Maria Guadalupe C", "Falcione Sar | Neurology | 2024 | 0 |
| Glymphatic system clears extracellular tau and protects from tau aggregation and [PMID:35212707] | Ishida K, Yamada K, Nishiyama R, Hashimo | The Journal of experimental me | 2022 | 0 |
| Glymphatic system clears extracellular tau and protects from tau aggregation and [PMID:35212707] | Ishida K, Yamada K, Nishiyama R, Hashimo | The Journal of experimental me | 2022 | 0 |
| Reactive astrocytes facilitate vascular repair and remodeling after stroke. [PMID:33910014] | Williamson MR, Fuertes CJA, Dunn AK | Cell Rep | 2021 | 0 |
| Multiscale dynamics of tight junction remodeling. [PMID:31754042] | Varadarajan S, Stephenson RE, Miller AL | J Cell Sci | 2019 | 0 |
| Retinal neurodegeneration and brain MRI markers: the Rotterdam Study. [PMID:28974335] | Mutlu, Bonnemaijer, Ikram, Colijn, Creme | Neurobiology of aging | 2018 | 0 |
| Tau protein aggregation is associated with cellular senescence in the brain. [PMID:30126037] | ["Musi Nicolas", "Valentine Joseph M", " | Aging cell | 2018 | 0 |
| Retinal neurodegeneration and brain MRI markers: the Rotterdam Study. [PMID:28974335] | Unknown | Neurobiology of aging | 2018 | 0 |
| Tau protein aggregation is associated with cellular senescence in the brain. [PMID:30126037] | ["Musi Nicolas", "Valentine Joseph M", " | Aging cell | 2018 | 0 |
| A/T/N: An unbiased descriptive classification scheme for Alzheimer disease bioma [PMID:27371494] | Jack, Bennett, Blennow, Carrillo, Feldma | Neurology | 2017 | 0 |
| Fluorescein Isothiocyanate (FITC)-Dextran Extravasation as a Measure of Blood-Br [PMID:28398646] | Natarajan R, Northrop N, Yamamoto B | Curr Protoc Neurosci | 2017 | 0 |
| A/T/N: An unbiased descriptive classification scheme for Alzheimer disease bioma [PMID:27371494] | Unknown | Neurology | 2017 | 0 |
| Impact of brain aging and neurodegeneration on cognition: evidence from MRI. [PMID:24184970] | Draganski, Lutti, Kherif | Current opinion in neurology | 2014 | 0 |
| Impact of brain aging and neurodegeneration on cognition: evidence from MRI. [PMID:24184970] | Unknown | Current opinion in neurology | 2014 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 3 · Score: 0.75 · 2026-04-26
closed · Rounds: 3 · Score: 0.75 · 2026-04-26
closed · Rounds: 4 · Score: 0.78 · 2026-04-26
Hypotheses and analyses mentioning tight-junction remodeling in their description or question text
No additional research found