Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about stiffness: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| Macrophage Function | regulates | process | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Matrix Stiffness Normalization via Targeted Lysyl Oxidase In | 0.709 | neurodegeneration | Perivascular spaces and glymphatic clear |
| Extracellular Matrix Stiffness Modulation | 0.691 | neurodegeneration | Microglia-astrocyte crosstalk amplificat |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Microglial activation by bEVs via Piezo1 | exploratory | Alzheimer's disease | 0.900 | 0.00 | microglia (in vivo and in vitr | proposed | N/A |
| Proposed experiment from debate on Perivascular spaces and glymphatic | falsification | Neurodegeneration | 0.400 | 0.50 | mouse | proposed | $240,000 |
| Biomechanical Impact Profiles and Chronic Traumatic Encephalopathy Phe | clinical | Neurodegeneration | 0.400 | 0.50 | in_silico | proposed | $200,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Brain Capillary Ion Channels: Physiology and Channelopathies. [PMID:40748720] | Harraz OF, Hashad AM | Physiology (Bethesda) | 2026 | 1 |
| Evolutionary conservation and Immunoregulatory function of LOXL3 gene in lamprey [PMID:40816690] | Pang Y, Yan Z, Gao Y, Li D, Zhao L, Ma G | Fish Shellfish Immunol | 2025 | 1 |
| Machine learning-based in-silico analysis identifies signatures of lysyl oxidase [PMID:40186284] | Xu Q, Ma L, Streuer A, Altrock E, Schmit | Cell Commun Signal | 2025 | 1 |
| Stiffness sensing via Piezo1 enhances macrophage efferocytosis and promotes the [PMID:38838160] | Wang Y, Wang J, Zhang J, Wang Y, Wang Y, | Sci Adv | 2024 | 1 |
| Mechanosensitive Piezo1 channel in physiology and pathophysiology of the central [PMID:37532007] | Zong B, Yu F, Zhang X, Pang Y, Zhao W, S | Ageing Res Rev | 2023 | 1 |
| Targeting extracellular matrix stiffness and mechanotransducers to improve cance [PMID:35331296] | Jiang Y, Zhang H, Wang J, Liu Y, Luo T, | J Hematol Oncol | 2022 | 1 |
| Mechanically activated ion channel Piezo1 modulates macrophage polarization and [PMID:34059671] | Atcha H, Jairaman A, Holt JR, Meli VS, N | Nat Commun | 2021 | 1 |
| Excessive compression induces cartilage endplate degeneration via the Piezo1/NAT [PMID:41175920] | Sun H, Wu Z, Zhang Y, Liu C, Gao D et al | Osteoarthritis Cartilage | 2026 | 0 |
| Liver Stiffness Rises Early in MASLD and Drives Inflammation, Lipid Dysmetabolis [PMID:41486513] | Ma J, Xie N, Wang Z, Liang X, Han Y et a | Adv Sci (Weinh) | 2026 | 0 |
| Insights into the role of the mechanosensitive Piezo1 channel and signaling mech [PMID:41544798] | Zhang M, Ge Y, Wang Z, Li H, Wang G et a | Neurosci Biobehav Rev | 2026 | 0 |
| Long-range chemical signalling in vivo is regulated by mechanical signals. [PMID:41555045] | Pillai EK, Mukherjee S, Gampl N, McGinn | Nat Mater | 2026 | 0 |
| The Glymphatic System and Meningeal Lymphatics: Current Understandings and Futur [PMID:41930354] | Sun H, Fan H, Zhou Y, Zhu H, Chen Y et a | MedComm (2020) | 2026 | 0 |
| Direct pharmacological targeting of Piezo1 by Paeoniflorin: a novel therapeutic [PMID:40653265] | ["Li R", "Xia J", "Shi C", "Zhang K", "Q | Journal of advanced research | 2026 | 0 |
| Piezo1 is a pathogenic gene and therapeutic target for neurological diseases. [PMID:40276938] | Wang H, Gou Z, Chen S, Lu L | The International journal of n | 2026 | 0 |
| Mechanosensitive channel Piezo1 in calcium dynamics: structure, function, and em [PMID:41195420] | Liu Y, Xu YQ, Long YY, Xiao H, Ma YY, Li | Frontiers in molecular bioscie | 2025 | 0 |
| Arteriolar degeneration and stiffness in cerebral amyloid angiopathy are linked [PMID:40465757] | ["Ventura-Antunes L", "Nackenoff A", "Ro | Alzheimer's & dementia : the j | 2025 | 0 |
| PIEZO1: a mechanosensitive ion channel in the pathogenesis and pharmacotherapy o [PMID:41051683] | Gupta T, Singh TG, Singh R | Molecular biology reports | 2025 | 0 |
| LOX-mediated ECM mechanical stress induces Piezo1 activation in hypoxic-ischemic [PMID:39260063] | ["Jiang D", "Zhao J", "Zheng J", "Zhao Y | Redox biology | 2024 | 0 |
| Cardiomyocyte senescence and the potential therapeutic role of senolytics in the [PMID:39119147] | ["Zhai P", "Sadoshima J"] | The journal of cardiovascular | 2024 | 0 |
| Osr2 functions as a biomechanical checkpoint to aggravate CD8+ T cell exhaustion [PMID:38744281] | Zhang J, Li J, Hou Y, Lin Y, Zhao H, Shi | Cell | 2024 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning stiffness in their description or question text
No additional research found