Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Sphingomyelin Synthesis: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
The transfer of phosphocholine from phosphatidylcholine to ceramide, catalyzed by sphingomyelin synthases SGMS1 and SGMS2 in the Golgi apparatus and plasma membrane. Sphingomyelin is the most abundant sphingolipid in myelin sheaths and neuronal membranes. Hydrolysis by acid sphingomyelinase (SMPD1) produces ceramide, linking sphingomyelin metabolism to apoptotic signaling in neurodegeneration.
Ontology: GO:0006686 · MESH:D054928
No AI portrait yet
| Name | sphingomyelin_synthesis |
| Key Genes/Proteins | SGMS1 |
| Related Diseases | membrane_fluidity |
| Target | Relation | Type | Str |
|---|---|---|---|
| membrane_fluidity | activates | phenotype | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| SGMS1 | modifies | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 13 hypotheses Top: 0.852
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 6 · Score: 0.95 · 2026-04-27
closed · Rounds: 4 · Score: 0.50 · 2026-04-27
closed · Rounds: 4 · Score: 0.40 · 2026-04-27
closed · Rounds: 4 · Score: 0.40 · 2026-04-27
closed · Rounds: 5 · Score: 0.93 · 2026-04-11
Hypotheses and analyses mentioning Sphingomyelin Synthesis in their description or question text
No additional research found