Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about sTREM2/membrane-TREM2/ADAM10: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| neuroimmunology | promoted: CSF sTREM2 as Pharmacodynamic Biomarker for Therapeutic Window Identification | disease | 0.67 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| CSF sTREM2 as Pharmacodynamic Biomarker for Therapeutic Wind | 0.801 | neuroimmunology | TREM2 in Alzheimer's Disease: Mechanisms |
Scientific analyses that reference this entity
neuroimmunology | 2026-04-15 | 1 hypotheses Top: 0.670
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Autophagy receptor identification for stress granule elimination | exploratory | neurodegenerative diseases | 0.900 | 0.00 | cultured cells under arsenite | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Neurodegeneration and demyelination in multiple sclerosis. [PMID:38889714] | Garton T, Gadani SP, Gill AJ, Calabresi | Neuron | 2024 | 0 |
| STING orchestrates the neuronal inflammatory stress response in multiple scleros [PMID:38878778] | Woo MS, Mayer C, Binkle-Ladisch L, Sonne | Cell | 2024 | 0 |
| Gasdermin-E mediates mitochondrial damage in axons and neurodegeneration. [PMID:36917977] | Neel DV, Basu H, Gunner G, Bergstresser | Neuron | 2023 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.59 · 2026-04-27
closed · Rounds: 4 · Score: 0.73 · 2026-04-15
Hypotheses and analyses mentioning sTREM2/membrane-TREM2/ADAM10 in their description or question text
No additional research found