Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about perforant path: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| hippocampal CA1 pyramidal neurons | activates | cell_type | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| EC-II | associated_with | brain_region | 0.90 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Closed-loop transcranial focused ultrasound targeting EC-II | 0.968 | Alzheimer's disease | Circuit-level neural dynamics in neurode |
| Closed-loop tACS targeting EC-II PV interneurons to suppress | 0.811 | Alzheimer's disease | Circuit-level neural dynamics in neurode |
| Perforant Path Presynaptic Terminal Protection Strategy | 0.696 | neurodegeneration | Selective vulnerability of entorhinal co |
| H2: Perforant Path Synapse Loss via Early Complement Cascade | 0.610 | neurodegeneration | Entorhinal cortex layer II vulnerability |
| Low-Intensity tFUS Modulation of EC-DG/EC-CA1 Perforant Path | 0.540 | Alzheimer's disease | Closed-loop transcranial focused ultraso |
Scientific analyses that reference this entity
neuroscience | 2026-04-03 | 73 hypotheses Top: 0.968
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Plant-based dietary patterns and Alzheimer's disease risk in multiethn | clinical | Alzheimer's disease and relate | 0.950 | 0.00 | human patients | proposed | N/A |
| PGC-1α knockout effects on PV+ interneuron maturation | validation | 0.900 | 0.00 | PGC-1α knockout mice | proposed | N/A | |
| PGC-1α expression analysis during PV+ interneuron development | exploratory | 0.800 | 0.00 | mouse cortex | proposed | N/A | |
| Activity-dependent regulation of PGC-1α in PV+ interneurons | exploratory | 0.800 | 0.00 | mouse cortical neurons | proposed | N/A | |
| Metabolic Pathway-Targeted Therapy in ALS | clinical | ALS | 0.400 | 0.50 | human | proposed | $6,550,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| A postnatal molecular switch drives activity-dependent maturation of parvalbumin [PMID:40669459] | Moissidis M, Abbasova L, Selten M, Alis | Cell | 2025 | 1 |
| The Role of PGC1α in Alzheimer's Disease and Therapeutic Interventions. [PMID:34071270] | Mota BC, Sastre M | Int J Mol Sci | 2021 | 1 |
| Insulin-stimulated endoproteolytic TUG cleavage links energy expenditure with gl [PMID:33686286] | Habtemichael EN, Li DT, Camporez JP, Wes | Nat Metab | 2021 | 1 |
| Metabolic effects of RUBCN/Rubicon deficiency in kidney proximal tubular epithel [PMID:31944172] | Matsuda J, Takahashi A, Takabatake Y, Sa | Autophagy | 2020 | 1 |
| Minutes of PPAR-γ agonism and neuroprotection. [PMID:32758586] | Prashantha Kumar BR, Kumar AP, Jose JA, | Neurochem Int | 2020 | 1 |
| Polystyrene microplastics induced spermatogenesis disorder via disrupting mitoch [PMID:39577614] | ["Jin H", "Xue B", "Chen X", "Ma T", "Ma | Environmental pollution (Barki | 2025 | 0 |
| Lipidomic and Transcriptomic Reveals Variations in Lipid Deposition During Goose [PMID:41300406] | Zhang Q, Bai C, Zhang M, Yue B, Zhang J, | Biology | 2025 | 0 |
| Blueberry anthocyanins ameliorate arsenic-induced cognitive impairment in rats: [PMID:40663938] | Ma X, Liu Y, Ding B, Liu Y, Zhang Y, Wan | Phytomedicine : international | 2025 | 0 |
| Deciphering the PGC-1α-TFAM Axis in Parkinson's Disease (PD) - A Mechanism Appro [PMID:41454214] | Iyer M, Kinoshita M, Reddy DH, Babu HWS, | Molecular neurobiology | 2025 | 0 |
| Cardioprotective effects of the jiming formula on myocardial metabolism in Mice [PMID:40220403] | Fan X, Wei X, Wang W, Chai W, Xiao J, Ha | Phytomedicine : international | 2025 | 0 |
| Tang Bi formula alleviates diabetic sciatic neuropathy via AMPK/PGC-1α/MFN2 path [PMID:40646155] | ["Yang C", "Yu H", "Zhou L", "Su H", "Li | Scientific reports | 2025 | 0 |
| Tetramethylpyrazine nitrone exerts neuroprotection via activation of PGC-1α/Nrf2 [PMID:37989471] | ["Guo B", "Zheng C", "Cao J", "Luo F", " | Journal of advanced research | 2024 | 0 |
| P-tau217 correlates with neurodegeneration in Alzheimer's disease, and targeting [PMID:38513667] | Zhang D, Zhang W, Ming C, Gao X, Yuan H, | Neuron | 2024 | 0 |
| The necroptosis cell death pathway drives neurodegeneration in Alzheimer's disea [PMID:38852117] | Balusu S, De Strooper B | Acta neuropathologica | 2024 | 0 |
| Insulin Resistance and Diabetes Mellitus in Alzheimer's Disease. [PMID:34069890] | Burillo J, Marqués P, Jiménez B, Gonzále | Cells | 2021 | 0 |
| Alcohol-related breast cancer in postmenopausal women - effect of CYP19A1, PPARG [PMID:27102200] | ["Kopp T", "Jensen D", "Ravn-Haren G", " | BMC cancer | 2016 | 0 |
| Effect of rosiglitazone on peroxisome proliferator-activated receptor gamma gene [PMID:18954260] | ["Mallon P", "Sedwell R", "Rogers G", "N | The Journal of infectious dise | 2008 | 0 |
| Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in tra [PMID:17021169] | ["Oakley, Holly", "Cole, Sarah L", "Loga | The Journal of neuroscience : | 2006 | 0 |
| The amyloid hypothesis of Alzheimer's disease: progress and problems on the road [PMID:12130773] | ["Hardy, John", "Selkoe, Dennis J"] | Science (New York, N.Y.) | 2002 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 6 · Score: 0.95 · 2026-04-27
closed · Rounds: 6 · Score: 0.95 · 2026-04-27
closed · Rounds: 4 · Score: 0.65 · 2026-04-27
closed · Rounds: 4 · Score: 0.71 · 2026-04-27
closed · Rounds: 4 · Score: 0.87 · 2026-04-27
closed · Rounds: 4 · Score: 0.48 · 2026-04-27
closed · Rounds: 4 · Score: 0.54 · 2026-04-27
closed · Rounds: 4 · Score: 0.19 · 2026-04-27
closed · Rounds: 4 · Score: 0.40 · 2026-04-27
closed · Rounds: 4 · Score: 0.50 · 2026-04-27
Hypotheses and analyses mentioning perforant path in their description or question text
No additional research found