Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about organelle_trafficking: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| KIF5 | regulates | protein | 0.85 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| TFAM overexpression creates mitochondrial donor-recipient gr | 0.725 | neurodegeneration | Mitochondrial transfer between astrocyte |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| IRI-AKI mouse model with mtROS inhibition | validation | ischemic acute kidney injury | 0.900 | 0.00 | IRI-AKI mice | proposed | N/A |
| mtROS effects on TFAM and mtDNA in HK2 cells | exploratory | acute kidney injury | 0.900 | 0.00 | HK2 cells | proposed | N/A |
| TFAM knockdown functional analysis | exploratory | acute kidney injury | 0.850 | 0.00 | HK2 cells | proposed | N/A |
| TFAM and mtDNA analysis in AKI patients | clinical | acute kidney injury | 0.800 | 0.00 | human patients | proposed | N/A |
| s:** - Test MCU overexpression specifically in layer II neurons in hea | falsification | Neurodegeneration | 0.400 | 0.50 | mouse | proposed | $200,000 |
| Proposed experiment from debate on Mitochondrial transfer between astr | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $80,000 |
| Selective Vulnerability of Dopaminergic Neurons — Mechanism and Protec | validation | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $160,000 |
| Exercise-BDNF-Mitophagy Biomarker Study in PD | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Ferroptosis Validation in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| GLP-1 Agonist Neuroprotection Mechanism in PD | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Melatonin attenuates sepsis-induced acute kidney injury by promoting mitophagy t [PMID:37651673] | Deng Z, He M, Hu H, Zhang W, Zhang Y, Ge | Autophagy | 2024 | 1 |
| TFAM is an autophagy receptor that limits inflammation by binding to cytoplasmic [PMID:38783142] | Liu H, Zhen C, Xie J, Luo Z, Zeng L, Zha | Nat Cell Biol | 2024 | 1 |
| Mitochondrial-derived damage-associated molecular patterns amplify neuroinflamma [PMID:35233090] | Lin MM, Liu N, Qin ZH, Wang Y | Acta Pharmacol Sin | 2022 | 1 |
| Mitochondrial ROS promote mitochondrial dysfunction and inflammation in ischemic [PMID:33408785] | Zhao M, Wang Y, Li L, Liu S, Wang C, Yua | Theranostics | 2021 | 1 |
| Mitochondrial DNA copy number in human disease: the more the better? [PMID:33314045] | Filograna R, Mennuni M, Alsina D, Larsso | FEBS Lett | 2021 | 1 |
| Mitochondrial DNA stress triggers autophagy-dependent ferroptotic death. [PMID:32186434] | Li C, Zhang Y, Liu J, Kang R, Klionsky D | Autophagy | 2021 | 1 |
| Butyrate extends health and lifespan in mice with mitochondrial deficiency. [PMID:41826362] | ["Gaband\u00e9-Rodr\u00edguez E", "G\u00 | Nature communications | 2026 | 0 |
| Vav-iCre-Mediated Deletion of TFAM Is Not Recoverable and Is Consistent with Emb [PMID:41898789] | ["Ghosh R", "Shakur E", "Yousefzadeh M"] | Genes | 2026 | 0 |
| NRIP1 co-activates nuclear translocated FOXO3 to upregulate TFAM expression and [PMID:41888517] | ["Zha Y", "Huang H", "Liu Y", "Wan M", " | Cell death discovery | 2026 | 0 |
| miR-137-5p-Loaded Milk-Derived Small Extracellular Vesicles Modulate Oxidative S [PMID:41754992] | ["G\u00f6n\u00fcll\u00fc S", "Ayd\u0131n | Pharmaceutics | 2026 | 0 |
| Ginseng stem and leaf saponins attenuates pulmonary fibrosis by regulating TFAM- [PMID:41911987] | Chen Y, Hu L, Fu Q, Chen H, Jiang Z, Li | Journal of ethnopharmacology | 2026 | 0 |
| Structural Analysis of Human LonP1 Protease Bound with the Native Substrate. [PMID:41900996] | Li M, Liu H, Zhang S, Gao Q, Li S, Wang | Life (Basel, Switzerland) | 2026 | 0 |
| Effect of (-)-Epicatechin on Mitochondrial Homeostasis in Skeletal Muscle of Fem [PMID:41900149] | Herrera-Cogco EC, Herrera-Meza S, Martín | Molecules (Basel, Switzerland) | 2026 | 0 |
| Enhancing the Optical Properties of MAPbI3 Perovskites Passivated with Coordinat [PMID:41908442] | Gamarde M, Jouaiti A, Chartrand D, Antho | ACS omega | 2026 | 0 |
| Butyrate extends health and lifespan in mice with mitochondrial deficiency. [PMID:41648569] | ["Gaband\u00e9-Rodr\u00edguez E", "G\u00 | bioRxiv : the preprint server | 2026 | 0 |
| PM [PMID:41897431] | ["Somayajulu M", "Wright R", "Muhammed F | Antioxidants (Basel, Switzerla | 2026 | 0 |
| m6A deficiency induces dopaminergic neurodegeneration and progressive parkinsoni [PMID:41842966] | ["Liu S", "Ren Q", "Mo G", "Li Z", "Huan | The Journal of clinical invest | 2026 | 0 |
| In vitro investigation of miR-206-3p-loaded extracellular vesicles as modulators [PMID:41592400] | ["G\u00f6n\u00fcll\u00fc S", "Ayd\u0131n | Biochemical and biophysical re | 2026 | 0 |
| Next-Generation Metabolic Reprogramming in iPSC-Derived Cardiomyocytes: CRISPR-E [PMID:41897402] | ["Shahannaz D", "Sugiura T"] | Biomolecules | 2026 | 0 |
| MitoPerturb-Seq identifies gene-specific single-cell responses to mitochondrial [PMID:41922875] | Burr SP, Auckland K, Glynos A, Dhawanjew | Nature structural & molecular | 2026 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning organelle_trafficking in their description or question text
No additional research found