Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about nanoparticle: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| blood brain barrier | modulates | brain_region | 0.75 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Astrocyte-Selective APOE4 Silencing via Lipid Nanoparticles | 0.682 | neurodegeneration | Which cell types show the most significa |
| Lipid Nanoparticle Encapsulation of IGFBPL1-mRNA | 0.527 | drug delivery | Can IGFBPL1 therapeutics effectively cro |
| Transcranial Magnetic Stimulation-Induced Nanoparticle Deliv | 0.380 | neurodegeneration | Blood-brain barrier antibody transport m |
| Magnetofection-Enhanced IGFBPL1 Delivery via Superparamagnet | 0.341 | drug delivery | Can IGFBPL1 therapeutics effectively cro |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-03 | 14 hypotheses Top: 0.850
neurodegeneration | 2026-04-02 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Multi-omics analysis of myricanol effects on gene expression and micro | exploratory | hyperlipidemia | 0.880 | 0.00 | C57BL/6J mouse liver and epidi | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Amelioration of Tau and ApoE4-linked glial lipid accumulation and neurodegenerat [PMID:37995685] | Litvinchuk A, Suh JH, Guo JL, Lin K, Dav | Neuron | 2024 | 1 |
| The cell biology of APOE in the brain. [PMID:37805344] | Windham IA, Cohen S | Trends Cell Biol | 2024 | 1 |
| APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia. [PMID:33658354] | Sienski G, Narayan P, Bonner JM, Kory N, | Sci Transl Med | 2021 | 1 |
| APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therape [PMID:33340485] | Serrano-Pozo A, Das S, Hyman BT | Lancet Neurol | 2021 | 1 |
| Modulating LRP1 Pathways in Alzheimer's Disease: Mechanistic Insights and Emergi [PMID:41772271] | Mushtaq T, Hameed H, Khan MA, Tariq U, H | Molecular neurobiology | 2026 | 0 |
| Alzheimer and cardiovascular genetic scores and cognition: the FINGER randomized [PMID:40747850] | Saadmaan G, Dalmasso MC, Maria M, Lehtis | Brain | 2026 | 0 |
| Postoperative cognitive dysfunction and neurodegeneration: From inflammation to [PMID:41679672] | Lin X, Luo Y, Zhu Q | Brain Res Bull | 2026 | 0 |
| Lipidome and proteome of astrocyte and microglia ApoE lipoprotein reveal differe [PMID:41692246] | Strickland MR, Wang Z, Golden LR, Wang H | J Lipid Res | 2026 | 0 |
| CRISPR-Cas9 and next-generation gene editing strategies for therapeutic interven [PMID:41931258] | Khan MS, Zafar I, Jamal A, Bahwerth FS, | Acta Neurol Belg | 2026 | 0 |
| Alzheimer's disease basics: we all should know. [PMID:40639927] | Das S | Neurological research | 2026 | 0 |
| APOE4 reprograms microglial lipid metabolism in Alzheimer's disease: Mechanisms [PMID:40835432] | ["Chen Jiajie", "Zhao Shuoyan", "Zhou Yi | Bioscience trends | 2026 | 0 |
| Genetic modifiers of APOE-ε4-associated cognitive decline. [PMID:41720779] | Contreras AG, Walters S, Eissman JM, Arc | Nature communications | 2026 | 0 |
| Protective ApoE variants support neuronal function by effluxing oxidized phospho [PMID:41338186] | Ralhan I, Do AD, Bae JY, Feringa FM, Cai | Neuron | 2026 | 0 |
| Viral and non-viral cellular therapies for neurodegeneration. [PMID:41585268] | ["Srivastav Jyotsna", "Sharma Sachin"] | Frontiers in medicine | 2025 | 0 |
| Cell type-specific roles of APOE4 in Alzheimer disease. [PMID:38191720] | ["Blumenfeld Jessica", "Yip Oscar", "Kim | Nature reviews. Neuroscience | 2024 | 0 |
| APOE traffics to astrocyte lipid droplets and modulates triglyceride saturation [PMID:38334983] | ["Windham Ian A", "Powers Alex E", "Ragu | The Journal of cell biology | 2024 | 0 |
| Regulation of astrocyte lipid metabolism and ApoE secretionby the microglial oxy [PMID:36849076] | ["Cashikar Anil G", "Toral-Rios Danira", | Journal of lipid research | 2023 | 0 |
| APOE4 impairs the microglial response in Alzheimer's disease by inducing TGFβ-me [PMID:37749326] | Yin Z, Rosenzweig N, Kleemann KL, Zhang | Nature immunology | 2023 | 0 |
| Cholesterol and matrisome pathways dysregulated in astrocytes and microglia. [PMID:35750033] | ["Tcw J", "Qian L", "Pipalia N", "Chao M | Cell | 2022 | 0 |
| APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therape [PMID:33340485] | Serrano-Pozo A, Das S, Hyman BT | Lancet Neurol | 2021 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.95 · 2026-04-03
closed · Rounds: 4 · Score: 0.90 · 2026-04-02
Hypotheses and analyses mentioning nanoparticle in their description or question text
No additional research found