Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about methylation changes: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| transcriptome | regulates | process | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| 34415665 | may be reflection of / involved in | paper | 0.30 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| protective chromatin remodeling defines the therapeutic wind | 0.345 | neurodegeneration | Are DNA methylation changes in neurodege |
| age-linked CpG drift is the actionable driver in: Are DNA me | 0.344 | neurodegeneration | Are DNA methylation changes in neurodege |
| age-linked CpG drift is the actionable driver in: Are age-re | 0.344 | neurodegeneration | Are age-related DNA methylation changes |
| ATAC-seq accessibility separates causal from compensatory st | 0.342 | neurodegeneration | Are DNA methylation changes in neurodege |
| ATAC-seq accessibility separates causal from compensatory st | 0.327 | neurodegeneration | Are age-related DNA methylation changes |
| protective chromatin remodeling defines the therapeutic wind | 0.326 | neurodegeneration | Are age-related DNA methylation changes |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-26 | 3 hypotheses Top: 0.344
neurodegeneration | 2026-04-10 | 0 hypotheses
neurodegeneration | 2026-04-10 | 7 hypotheses Top: 0.700
neurodegeneration | 2026-04-04 | 9 hypotheses Top: 0.969
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS [PMID:33031745] | Yu CH, Davidson S, Harapas CR, Hilton JB | Cell | 2020 | 2 |
| Genome-wide methylation profiles reveal quantitative views of human aging rates. [PMID:23177740] | Hannum G, Guinney J, Zhao L, Zhang L, Hu | Mol Cell | 2013 | 1 |
| DNA methylation and prediction of biological age. [PMID:41602542] | Chen Y, Cheng X, Ji S | Front Mol Biosci | 2025 | 0 |
| Causality-enriched epigenetic age uncouples damage and adaptation. [PMID:38243142] | Ying K, Liu H, Tarkhov AE | Nat Aging | 2024 | 0 |
| PARP1-DNA co-condensation drives DNA repair site assembly to prevent disjunction [PMID:38320550] | Chappidi, Quail, Doll, Vogel, Aleksandro | Cell | 2024 | 0 |
| DNA-Origami-Armored DNA Condensates. [PMID:39075031] | Yamashita, Sato, Suzuki, Ishikawa, Takin | Chembiochem : a European journ | 2024 | 0 |
| PARP1-DNA co-condensation drives DNA repair site assembly to prevent disjunction [PMID:38320550] | Chappidi Nagaraja; Quail Thomas; Doll Si | Cell | 2024 | 0 |
| Causality-enriched epigenetic age uncouples damage and adaptation. [PMID:38243142] | Ying K, Liu H, Tarkhov AE, Sadler MC, Lu | Nature aging | 2024 | 0 |
| DNA-Origami-Armored DNA Condensates. [PMID:39075031] | Unknown | Chembiochem : a European journ | 2024 | 0 |
| Single substitution in H3.3G34 alters DNMT3A recruitment to cause progressive ne [PMID:36931244] | Khazaei Sima; Chen Carol C L; Andrade Au | Cell | 2023 | 0 |
| Neurodegeneration and epigenetics: A review. [PMID:37344098] | Ghosh P, Saadat A | Neurologia (Engl Ed) | 2023 | 0 |
| Regulation of Human DNA Primase-Polymerase PrimPol. [PMID:37758313] | Boldinova, Makarova | Biochemistry. Biokhimiia | 2023 | 0 |
| Global identification of SWI/SNF targets reveals compensation by EP400. [PMID:37922899] | Martin BJE, Ablondi EF, Goglia C | Cell | 2023 | 0 |
| Regulation of Human DNA Primase-Polymerase PrimPol. [PMID:37758313] | Unknown | Biochemistry. Biokhimiia | 2023 | 0 |
| Neurodegeneration and epigenetics: A review. [PMID:37344098] | ["Ghosh P", "Saadat A"] | Neurologia | 2023 | 0 |
| Site-specific mitochondrial dysfunction in neurodegeneration. [PMID:35182728] | Vodičková A, Koren SA, Wojtovich AP | Mitochondrion | 2022 | 0 |
| Chromatin accessibility profiling by ATAC-seq. [PMID:35478247] | Grandi Fiorella C; Modi Hailey; Kampman | Nature protocols | 2022 | 0 |
| DNA damage and repair in age-related inflammation. [PMID:35831609] | Zhao Yang; Simon Matthew; Seluanov Andre | Nature reviews. Immunology | 2022 | 0 |
| Bone remodeling: an operational process ensuring survival and bone mechanical co [PMID:35851054] | Bolamperti Simona; Villa Isabella; Rubin | Bone research | 2022 | 0 |
| Chromatin accessibility profiling by ATAC-seq. [PMID:35478247] | Unknown | Nature protocols | 2022 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.00 · 2026-04-27
closed · Rounds: 3 · Score: 0.75 · 2026-04-26
closed · Rounds: 3 · Score: 0.75 · 2026-04-26
closed · Rounds: 4 · Score: 0.78 · 2026-04-26
closed · Rounds: 4 · Score: 0.50 · 2026-04-21
closed · Rounds: 0 · Score: 0.48 · 2026-04-21
closed · Rounds: 0 · Score: 0.51 · 2026-04-21
closed · Rounds: 4 · Score: 0.73 · 2026-04-21
closed · Rounds: 0 · Score: 0.52 · 2026-04-21
closed · Rounds: 0 · Score: 0.58 · 2026-04-21
Hypotheses and analyses mentioning methylation changes in their description or question text