entity

membranes

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about membranes: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1Connections

5Hypotheses

3Analyses

0Outgoing

1Incoming

0Experiments

7Debates

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Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (1)

Source	Relation	Type	Str
GALA peptide	disrupts	peptide	0.70

Targeting Hypotheses (5)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Differential Complement Regulator Expression on Synaptic Mem	0.783	synaptic biology	What determines the selectivity of compl
ω-3 Docosahexaenoic Acid (DHA) Epoxide Generation via CYP2J2	0.752	lipidomics	Lipid metabolism dysregulation in Alzhei
ACSL4 lipid remodeling creates ferroptosis-prone ALS membran	0.710	neurodegeneration	Ferroptosis in ALS motor neuron vulnerab
Galectin-3 as Damage-Sensor Scaffold for Multimeric Cross-Se	0.455	neurodegeneration	Protein aggregation cross-seeding across
Reticulocalbin-2 bridges calcineurin to lysosomal membranes	0.360	neurodegeneration	What determines the specificity of calci

Mentioning Analyses (3)

Scientific analyses that reference this entity

How do synthetic EVs achieve brain-specific targeting while avoiding reticuloend

drug delivery | 2026-04-15 | 0 hypotheses

What molecular mechanisms cause iPLA2β deficiency to specifically damage mitocho

neurodegeneration | 2026-04-15 | 0 hypotheses

Lipid raft composition changes in synaptic neurodegeneration

neurodegeneration | 2026-04-01 | 13 hypotheses Top: 0.852

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (4)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Memorable Food: Fighting Age-Related Neurodegeneration by Precision Nutrition. [PMID:34422879]	["Milo\u0161evi\u0107 M", "Arsi\u0107 A"	Frontiers in nutrition	2021
Dietary DHA and health: cognitive function ageing. [PMID:27866493]	Unknown	Nutr Res Rev	2016
Docosahexaenoic acid and synaptic protection in Alzheimer's disease mice. [PMID:20211757]	Unknown	Biochim Biophys Acta	2010
Survival signalling in Alzheimer's disease. [PMID:17073801]	Unknown	Biochem Soc Trans	2006

Debates (7)

Multi-agent debates referencing this entity

Extended debate: CYP46A1 Overexpression Gene Therapy

closed · Rounds: 6 · Score: 0.95 · 2026-04-27

Hypothesis debate: Membrane Cholesterol Gradient Modulators

closed · Rounds: 4 · Score: 0.50 · 2026-04-27

Hypothesis debate: Selective Acid Sphingomyelinase Modulation Therapy

closed · Rounds: 4 · Score: 0.40 · 2026-04-27

Hypothesis debate: CYP46A1 Overexpression Gene Therapy

closed · Rounds: 4 · Score: 0.40 · 2026-04-27

The abstract shows that damaged mitochondrial inner membranes appear early in PL

closed · Rounds: 4 · Score: 0.95 · 2026-04-16

All participants identified brain delivery as a critical barrier, but no mechani

closed · Rounds: 4 · Score: 0.50 · 2026-04-16

Investigate how lipid raft composition (cholesterol metabolism, sphingolipids) c

closed · Rounds: 5 · Score: 0.93 · 2026-04-11

Related Research

Hypotheses and analyses mentioning membranes in their description or question text

No additional research found