Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about maresin biosynthesis: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| ALOX12 | regulates | gene | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Circadian-Gated Maresin Biosynthesis Amplification | 0.557 | neurodegeneration | Neuroinflammation resolution mechanisms |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| s:** - ALOX15 overexpression in healthy astrocytes should be protectiv | falsification | Neuroinflammation | 0.400 | 0.50 | mouse | proposed | $200,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Allosteric properties of mammalian ALOX15 orthologs. [PMID:41654134] | Yang J, Borchert A, Kuhn H | J Biol Chem | 2026 | 1 |
| SBFI26 induces triple-negative breast cancer cells ferroptosis via lipid peroxid [PMID:38516826] | He G, Zhang Y, Feng Y, Chen T, Liu M, Ze | J Cell Mol Med | 2024 | 1 |
| ALOX12 is required for p53-mediated tumour suppression through a distinct ferrop [PMID:30962574] | Chu B, Kon N, Chen D, Li T, Liu T, Jiang | Nat Cell Biol | 2019 | 1 |
| Emerging role of 12/15-Lipoxygenase (ALOX15) in human pathologies. [PMID:30472260] | Singh NK, Rao GN | Prog Lipid Res | 2019 | 1 |
| An ALOX12-12-HETE-GPR31 signaling axis is a key mediator of hepatic ischemia-rep [PMID:29227475] | Zhang XJ, Cheng X, Yan ZZ, Fang J, Wang | Nat Med | 2018 | 1 |
| Pharmacological and bioinformatics analysis reveals the reno-protective mechanis [PMID:41270547] | ["Ruiping L", "Yafeng W", "Liuyun L", "X | Computational biology and chem | 2026 | 0 |
| Hepatic Effects of Etoricoxib in Mice: Integrated Histopathological and Gene Exp [PMID:41901261] | ["Jamous Y", "Alghamdi B", "Jarrar Y", " | Pharmaceuticals (Basel, Switze | 2026 | 0 |
| Association of TyG index and [PMID:41757381] | ["Yin Y", "Yang M", "Deng W", "Zheng W"] | Journal of diabetes and metabo | 2026 | 0 |
| Luteolin alleviates ox-LDL-induced endothelial cell inflammation, apoptosis and [PMID:41633065] | ["Yang B", "Zhang H", "Fang S", "Liu Y", | Molecular immunology | 2026 | 0 |
| Oroxylin A attenuates sepsis-associated coagulopathy by targeting the ALOX12-lip [PMID:41794265] | ["Bai D", "Lu J", "Yang H", "Zhou C", "Z | Biochemical pharmacology | 2026 | 0 |
| Pan-PPAR agonist bezafibrate alleviates psoriasis by suppressing LCN2-dependent [PMID:41662914] | ["Xin R", "Zhang J", "Zhang Y", "Dai M", | Free radical biology & medicin | 2026 | 0 |
| Sevoflurane exposure triggers ferroptosis of neuronal cells initiated by the act [PMID:40378436] | ["Gu W", "Pan T", "Wang X", "Kang L", "L | International immunopharmacolo | 2025 | 0 |
| Typhae Pollen active subfraction exerts antiangiogenic effect in benign prostati [PMID:40934757] | Chen L, Chen D, Li J, Guo J, Lin M, Chen | Phytomedicine : international | 2025 | 0 |
| Resolution of experimental malaria-associated acute respiratory distress syndrom [PMID:40615878] | Prenen F, De Pauw B, Knoops S, Pollenus | Malaria journal | 2025 | 0 |
| Eicosanoid biosynthesizing enzymes in Prototheria. [PMID:39389415] | Kakularam KR, Gündem E, Stehling S, Roth | Biochimica et biophysica acta. | 2025 | 0 |
| Inhibition of ALOX12-12-HETE Alleviates Lung Ischemia-Reperfusion Injury by Redu [PMID:39268501] | ["Li C", "Gao P", "Zhuang F", "Wang T", | Research (Washington, D.C.) | 2024 | 0 |
| The involvement of IRP2-induced ferroptosis through the p53-SLC7A11-ALOX12 pathw [PMID:38936518] | ["Yao Z", "Jia F", "Wang S", "Jiao Q", " | Free radical biology & medicin | 2024 | 0 |
| Hydroperoxidation of Docosahexaenoic Acid by Human ALOX12 and pigALOX15-mini-LOX [PMID:37047037] | Canyelles-Niño M, González-Lafont À, Llu | International journal of molec | 2023 | 0 |
| Impact of pharmacogenetics on aspirin resistance: a systematic review. [PMID:36918009] | ["Silva G", "Lopes B", "Moser V", "Ferre | Arquivos de neuro-psiquiatria | 2023 | 0 |
| Pharmacological inhibition of arachidonate 12-lipoxygenase ameliorates myocardia [PMID:34536344] | ["Zhang X", "Liu X", "Hu M", "Zhao G", " | Cell metabolism | 2021 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning maresin biosynthesis in their description or question text
No additional research found