Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about lipid nanoemulsion therapy: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| APOE4 lipid transport capacity | therapeutic_target_for | process | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| APOE4-Selective Lipid Nanoemulsion Therapy | 0.742 | neurodegeneration | Mechanistic role of APOE in neurodegener |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| The APOE-R136S mutation protects against APOE4-driven Tau pathology, neurodegene [PMID:37957317] | Maxine R Nelson, Peng Liu, Ayushi Agrawa | Nature neuroscience | 2023 | 1 |
| The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Mic [PMID:28930663] | Krasemann S, Madore C, Cialic R, Baufeld | Immunity | 2017 | 1 |
| Perioperative polygenic and APOE-based genetic risk assessment for neurocognitiv [PMID:40562635] | Thedim M, Hu J, Maher M, Wiener-Kronish | Br J Anaesth | 2026 | 0 |
| Increased genetic protection against Alzheimer's disease in centenarians. [PMID:40615639] | Bae H, Song Z, Ali A, Sasaki T, Tesi N e | Geroscience | 2026 | 0 |
| Integrative machine learning approach to risk prediction for dementia and Alzhei [PMID:40864401] | Stern A, Linial M | Geroscience | 2026 | 0 |
| Multimodal Antiatherosclerotic Effects of Clinical-Grade Mesenchymal Stem Cell-D [PMID:41503702] | Kim J, Park D, Yoo J, Kim JE, Kim EH et | Stroke | 2026 | 0 |
| Menopause, cognition, and Alzheimer's disease risk. [PMID:41531227] | Samudra N, Vemuri M, Weitlauf J | Curr Opin Obstet Gynecol | 2026 | 0 |
| DPP4-regulated endothelial cell ferroptosis modulates atherosclerosis progressio [PMID:41565199] | Zheng L, Liang K, Peng Y, Jin M, Chen X | J Mol Cell Cardiol | 2026 | 0 |
| Inflammation-related miR-155-5p as an APOE ε4-modulated biomarker for amyloid pa [PMID:41930593] | Yoshida K, Saito N, Takahashi R, Ando S, | J Alzheimers Dis | 2026 | 0 |
| Neuropsychiatric symptoms and apolipoprotein E genotypes in neurocognitive disor [PMID:40145985] | Lozupone M, Leccisotti I, Mollica A, Ber | Neural regeneration research | 2026 | 0 |
| Cognitive Decline and Neurodegenerative Markers in Psoriasis: The Role of APOE4 [PMID:41912201] | Sabry HH, Kadhum BQ, Abdulmohsin GN, El- | Dermatology practical & concep | 2026 | 0 |
| Astrocytic APOE3-Christchurch expression ameliorates brain amyloid-β pathology i [PMID:41916957] | Raulin AC, Alnobani A, Rodriguez-Martine | Translational psychiatry | 2026 | 0 |
| Effects of APOE ε4 and amyloid pathology on longitudinal tau biomarkers, neurode [PMID:41910460] | Wang X, Zhang C, Liu X, Tai Y, Ma G, Kon | Journal of Alzheimer's disease | 2026 | 0 |
| Age at natural menopause, reproductive lifespan and Alzheimer's disease in femal [PMID:41884619] | Bruno F, Spadafora P, Abondio P, Qualtie | Frontiers in genetics | 2026 | 0 |
| Blood-brain-barrier-crossing lipid nanoparticles for mRNA delivery to the centra [PMID:39962245] | Wang C, Xue Y, Markovic T, Li H, Wang S, | Nature materials | 2025 | 0 |
| ApoE isoform- and microbiota-dependent progression of neurodegeneration in a mou [PMID:36634180] | ["Seo D", "O'Donnell D", "Jain N", "Ulri | Science (New York, N.Y.) | 2023 | 0 |
| The APOE-R136S mutation protects against APOE4-driven Tau pathology, neurodegene [PMID:37957317] | Nelson MR, Liu P, Agrawal A, Yip O, Blum | Nat Neurosci | 2023 | 0 |
| Extension study of the safety and efficacy of CLS-TA for treatment of macular oe [PMID:33712478] | Khurana RN, Merrill P, Yeh S, Suhler E, | The British journal of ophthal | 2022 | 0 |
| Lactate is an epigenetic metabolite that drives survival in model systems of gli [PMID:35948010] | Torrini C, Nguyen TTT, Shu C, Mela A, Hu | Molecular cell | 2022 | 0 |
| Neuronal ApoE upregulates MHC-I expression to drive selective neurodegeneration [PMID:33958804] | Zalocusky KA, Najm R, Taubes AL, Hao Y, | Nature neuroscience | 2021 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning lipid nanoemulsion therapy in their description or question text
No additional research found