Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Inflammasome Complex: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
A multi-protein complex that activates caspase-1-mediated inflammatory responses. The NLRP3 inflammasome is the best-characterized, consisting of NLRP3 sensor, ASC adaptor (PYCARD), and pro-caspase-1. Assembly triggers IL-1β and IL-18 maturation and pyroptotic cell death. NLRP3 inflammasome activation is driven by amyloid-β, α-synuclein, and tau aggregates in neurodegenerative diseases.
Ontology: GO:0061702 · MESH:D000077192
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| Name | inflammasome_activation |
| Key Genes/Proteins | NLRP3 |
| Linked Hypotheses | 13 hypotheses |
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| NLRP3 | activates | gene | 0.70 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
clinical neurology | 2026-04-08 | 7 hypotheses Top: 0.455
neuroscience | 2026-04-04 | 7 hypotheses Top: 0.679
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiqui [PMID:30966861] | ["Han X", "Sun S", "Sun Y", "Song Q", "Z | Autophagy | 2020 | 1 |
| Inhibition of autophagy in microglia and macrophages exacerbates innate immune r [PMID:36652438] | Hegdekar N, Sarkar C, Bustos S, Ritzel R | Autophagy | 2023 | 0 |
| Parkin regulates microglial NLRP3 and represses neurodegeneration in Parkinson's [PMID:37029500] | Yan YQ, Zheng R, Liu Y, Ruan Y, Lin ZH, | Aging cell | 2023 | 0 |
| Inflammasome assembly in neurodegenerative diseases. [PMID:37633753] | Singh J, Habean ML, Panicker N | Trends in neurosciences | 2023 | 0 |
| Microglial NLRP3 inflammasome activates neurotoxic astrocytes in depression-like [PMID:36288697] | Li S, Fang Y, Zhang Y, Song M, Zhang X, | Cell reports | 2022 | 0 |
| Biomarker of Neuroinflammation in Parkinson's Disease. [PMID:35456966] | Liu TW, Chen CM, Chang KH | Int J Mol Sci | 2022 | 0 |
| NLRP3/caspase-1/GSDMD-mediated pyroptosis exerts a crucial role in astrocyte pat [PMID:34877938] | Li S, Sun Y, Song M, Song Y, Fang Y, Zha | JCI insight | 2021 | 0 |
| NLRP3 inflammasome activation drives tau pathology. [PMID:31748742] | ["Ising C", "Venegas C", "Zhang S", "Sch | Nature | 2019 | 0 |
| Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodeg [PMID:30381407] | Gordon R, Albornoz EA, Christie DC, Lang | Science translational medicine | 2018 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.76 · 2026-04-22
closed · Rounds: 4 · Score: 0.79 · 2026-04-09
Hypotheses and analyses mentioning Inflammasome Complex in their description or question text
Score: 0.620 · neuroscience · 2026-04-22
## Mechanistic Overview Selective cathepsin B inhibition prevents cathepsin leakage-mediated NLRP3 inflammasome activati
Score: 0.617 · neurodegeneration · 2026-04-22
**Molecular Mechanism and Rationale** The proposed LRP1/NLRP3/IL-1β cascade represents a critical mechanistic link betw
Score: 0.380 · immunomics · 2026-04-27
Elevated circulating high-sensitivity C-reactive protein (hs-CRP) serves as a disease-modifying target through direct ac