Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about hippocampal_circuit: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| MAPT | disrupts | gene | 0.80 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Cholinergic Basal Forebrain-Hippocampal Circuit Protection | 0.760 | neuroscience | Circuit-level neural dynamics in neurode |
| Dopaminergic Ventral Tegmental-Hippocampal Circuit Protectio | 0.751 | neuroscience | Circuit-level neural dynamics in neurode |
| Locus Coeruleus-Hippocampal Circuit Protection | 0.668 | neuroscience | Circuit-level neural dynamics in neurode |
Scientific analyses that reference this entity
neuroscience | 2026-04-03 | 70 hypotheses Top: 0.964
neuroscience | 2026-04-02 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Plasma ATN biomarkers across AD continuum in Chilean cohort | clinical | Alzheimer's disease | 0.950 | 0.00 | Chilean older adults (n=318) w | proposed | N/A |
| Tau depletion effects on neuronal development in primary cultures | exploratory | 0.900 | 0.00 | primary rodent neuronal cultur | proposed | N/A | |
| Differential GWAS of schizophrenia vs PTSD | exploratory | schizophrenia, post-traumatic | 0.900 | 0.00 | human patients - European ance | proposed | N/A |
| Tau depletion effects on neuronal development in primary cultures | exploratory | 0.900 | 0.00 | primary rodent neuronal cultur | proposed | N/A | |
| Creation and validation of 3xAD-ChAT-Cre mouse model | validation | Alzheimer's disease | 0.900 | 0.00 | 3xAD-ChAT-Cre transgenic mice | proposed | N/A |
| GTEx brain tissue expression analysis of MAPT/CRHR1 locus | exploratory | schizophrenia, post-traumatic | 0.850 | 0.00 | human brain tissue samples fro | proposed | N/A |
| Microtubule domain analysis in adult axons | exploratory | 0.800 | 0.00 | adult rodent axons | proposed | N/A | |
| Tau depletion effects on microtubule domains in adult axons | exploratory | 0.800 | 0.00 | adult rodent neurons | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Predicting onset of symptomatic Alzheimer's disease with plasma p-tau217 clocks. [PMID:41714746] | ["Petersen Kellen K", "Mil\u00e0-Alom\u0 | Nature medicine | 2026 | 0 |
| A minimally invasive dried blood spot biomarker test for the detection of Alzhei [PMID:41491101] | Huber H, Montoliu-Gaya L, Brum WS, Vávra | Nat Med | 2026 | 0 |
| Experimental and translational models of Alzheimer's disease: From neurodegenera [PMID:41619411] | Khan N, De S, Boddu S, Pravala N | J Prev Alzheimers Dis | 2026 | 0 |
| TP53/TAU axis regulates microtubule bundling to control alveolar stem cell-media [PMID:41642658] | Konishi S, Enkhbayar K, Liu S, Miyashita | J Clin Invest | 2026 | 0 |
| Spontaneous tauopathy with parkinsonism in an aged cynomolgus macaque. [PMID:41695270] | Takahashi M, Taniguchi D, Funayama M, Ci | Front Aging Neurosci | 2026 | 0 |
| Differential genome-wide association analysis of schizophrenia and post-traumati [PMID:41767305] | Cheng ZS | Front Genet | 2026 | 0 |
| Genetic architecture of plasma pTau217 and related biomarkers in Alzheimer's dis [PMID:41804841] | Kim JP, Song M, Cho M, Lee H, Jung SH et | Alzheimers Dement | 2026 | 0 |
| Shared genetic architecture between Parkinson's disease and self-reported sleep- [PMID:41822813] | Aguilar-Roldán A, Ogonowski NS, Rentería | Sleep Adv | 2026 | 0 |
| Astroglial and Neuronal Injury Markers (GFAP, UCHL-1, NfL, Tau, S100B) as Diagno [PMID:41828591] | Ogłodek EA, Bar M | Int J Mol Sci | 2026 | 0 |
| CRISPR-Cas9 and next-generation gene editing strategies for therapeutic interven [PMID:41931258] | Khan MS, Zafar I, Jamal A, Bahwerth FS, | Acta Neurol Belg | 2026 | 0 |
| Alzheimer's disease basics: we all should know. [PMID:40639927] | Das S | Neurological research | 2026 | 0 |
| Progressive Supranuclear Palsy-A Global Review. [PMID:40898879] | Kukkle PL, Neupane R, Pantelyat A, Wills | Movement disorders clinical pr | 2026 | 0 |
| NAD+ restores proteostasis through splicing-dependent autophagy. [PMID:41313318] | Ai R, Fang EF | Autophagy | 2026 | 0 |
| Viral and non-viral cellular therapies for neurodegeneration. [PMID:41585268] | ["Srivastav Jyotsna", "Sharma Sachin"] | Frontiers in medicine | 2025 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 6 · Score: 0.95 · 2026-04-27
closed · Rounds: 6 · Score: 0.95 · 2026-04-27
closed · Rounds: 4 · Score: 0.65 · 2026-04-27
closed · Rounds: 4 · Score: 0.71 · 2026-04-27
closed · Rounds: 4 · Score: 0.87 · 2026-04-27
closed · Rounds: 4 · Score: 0.48 · 2026-04-27
closed · Rounds: 4 · Score: 0.54 · 2026-04-27
closed · Rounds: 4 · Score: 0.19 · 2026-04-27
closed · Rounds: 4 · Score: 0.40 · 2026-04-27
closed · Rounds: 4 · Score: 0.50 · 2026-04-27
Hypotheses and analyses mentioning hippocampal_circuit in their description or question text
No additional research found