entity

hcar2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about hcar2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

9Connections

1Hypotheses

1Analyses

2Outgoing

7Incoming

0Experiments

1Debates

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Outgoing (2)

Target	Relation	Type	Str
h-5b35f7a5	targeted_by	hypothesis	1.00
neurodegeneration	promoted: Beta-Hydroxybutyrate Receptor (HCAR2) Signaling Links Ketone Deficiency to Neuroinflammation	disease	0.65

Incoming (7)

Source	Relation	Type	Str
h-5b35f7a5	targets	hypothesis	1.00
35320002	expressed selectively by	paper	0.90
35320002	induced by	paper	0.90
35320002	required for	paper	0.90
35320002	is required for	paper	0.90
35320002	is expressed selectively by	paper	0.90
35320002	is robustly induced by	paper	0.90

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Beta-Hydroxybutyrate Receptor (HCAR2) Signaling Links Ketone	0.808	neurodegeneration	What are the precise temporal dynamics o

Mentioning Analyses (1)

Scientific analyses that reference this entity

What are the precise temporal dynamics of astrocyte ketone production decline du

neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.808

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (5)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554]	Marogianni C, Sokratous M, Dardiotis E,	International journal of molec	2020
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554]	Marogianni C, Sokratous M, Dardiotis E,	International journal of molec	2020
Multiple Sclerosis Pathology. [PMID:29358320]	Lassmann H	Cold Spring Harbor perspective	2018

Debates (1)

Multi-agent debates referencing this entity

The debate identified a critical therapeutic window when astrocytic ketone produ

closed · Rounds: 4 · Score: 0.85 · 2026-04-15

Related Research

Hypotheses and analyses mentioning hcar2 in their description or question text

No additional research found